Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 3/20 | 0.52 |
| ▸ | JAK3 | P52333 | 3/20 | 0.52 |
| ▸ | JAK1 | P23458 | 1/20 | 0.52 |
| ▸ | TYK2 | P29597 | 1/20 | 0.52 |
| ▸ | STAT3 | P40763 | 1/20 | 0.52 |
| ▸ | BRD4 | O60885 | 10/20 | 0.49 |
| ▸ | CCNT1 | O60563 | 4/20 | 0.49 |
| ▸ | CCNA2 | P20248 | 4/20 | 0.49 |
| ▸ | CDK2 | P24941 | 4/20 | 0.49 |
| ▸ | CDK9 | P50750 | 4/20 | 0.49 |
| ▸ | CDK1 | P06493 | 3/20 | 0.47 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.47 |
| ▸ | CDK7 | P50613 | 3/20 | 0.47 |
| ▸ | CCNH | P51946 | 3/20 | 0.47 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.47 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.47 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | FYN | P06241 | 1/20 | 0.47 |
| ▸ | CSF1R | P07333 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3967354 | 0.84 | CCNA2 (0.53) | JAK2JAK3JAK1TYK2STAT3 | |
| SCHEMBL3970767 | 0.83 | TTK (0.55) | JAK2JAK3JAK1BRD4EGFR | |
| SCHEMBL3968313 | 0.83 | JAK2 (0.57) | JAK2JAK3JAK1TYK2STAT3 | |
| SCHEMBL3964125 | 0.81 | AXL (0.53) | JAK2JAK3JAK1TYK2BRD4 | |
| SCHEMBL3965904 | 0.79 | TNK2 (0.54) | JAK2JAK3JAK1TYK2STAT3 | |
| SCHEMBL3971207 | 0.77 | CCNA2 (0.63) | JAK2JAK3JAK1BRD4CCNT1 | |
| SCHEMBL3966520 | 0.72 | TTK (0.55) | JAK2JAK3JAK1BRD4FLT3 | |
| SCHEMBL29310350 | 0.71 | SLC2A1 (0.60) | JAK2JAK3JAK1TYK2STAT3 | |
| SCHEMBL29310349 | 0.71 | ALK (0.60) | JAK2JAK3BRD4CCNT1CCNA2 | |
| SCHEMBL2479934 | 0.71 | NPC1 (0.60) | JAK2JAK3JAK1TYK2STAT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009046416-A1 | ANILINOPYRIMIDINES AS JAK KINASE INHIBITORS | TARGEGEN INC. (US) | 2009-04-09 | — | — | WO | claimed |
| WO-2009046416-A1 | ANILINOPYRIMIDINES AS JAK KINASE INHIBITORS | TARGEGEN INC. (US) | 2009-04-09 | — | — | WO | disclosed |
| WO-2009046416-A1 | ANILINOPYRIMIDINES AS JAK KINASE INHIBITORS | TARGEGEN INC. (US) | 2009-04-09 | — | — | WO | disclosed |