Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 15/20 | 0.53 |
| ▸ | CCNA2 | P20248 | 13/20 | 0.53 |
| ▸ | CCNT1 | O60563 | 12/20 | 0.53 |
| ▸ | CDK9 | P50750 | 12/20 | 0.53 |
| ▸ | JAK2 | O60674 | 3/20 | 0.49 |
| ▸ | JAK3 | P52333 | 3/20 | 0.49 |
| ▸ | JAK1 | P23458 | 1/20 | 0.47 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.47 |
| ▸ | AURKA | O14965 | 2/20 | 0.47 |
| ▸ | CDK1 | P06493 | 5/20 | 0.46 |
| ▸ | CCNB1 | P14635 | 5/20 | 0.46 |
| ▸ | CDK7 | P50613 | 5/20 | 0.46 |
| ▸ | CCNH | P51946 | 5/20 | 0.46 |
| ▸ | BRD4 | O60885 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13881589 | 0.90 | CDK2 (0.58) | CDK2CCNA2CCNT1CDK9JAK2 | |
| SCHEMBL4082156 | 0.88 | CDK2 (0.54) | CDK2CCNA2CCNT1CDK9JAK2 | |
| SCHEMBL3965469 | 0.86 | CDK2 (0.52) | CDK2CCNA2CCNT1CDK9JAK2 | |
| SCHEMBL3973289 | 0.86 | CDK2 (0.52) | CDK2CCNA2CCNT1CDK9JAK2 | |
| SCHEMBL3969755 | 0.82 | JAK2 (0.70) | CDK2CCNA2CCNT1CDK9JAK2 | |
| SCHEMBL3973041 | 0.79 | CDK2 (0.59) | CDK2CCNA2CCNT1CDK9JAK2 | |
| SCHEMBL13883500 | 0.76 | JAK2 (0.46) | CDK2CCNA2CCNT1CDK9JAK2 | |
| SCHEMBL3971546 | 0.75 | CDK2 (0.45) | CDK2CCNA2CCNT1CDK9JAK2 | |
| SCHEMBL13883685 | 0.74 | JAK2 (0.44) | CDK2CCNA2JAK2JAK3JAK1 | |
| SCHEMBL13883690 | 0.74 | JAK2 (0.43) | CDK2CCNA2CCNT1CDK9JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009046416-A1 | ANILINOPYRIMIDINES AS JAK KINASE INHIBITORS | TARGEGEN INC. (US) | 2009-04-09 | — | — | WO | disclosed |
| WO-2009046416-A1 | ANILINOPYRIMIDINES AS JAK KINASE INHIBITORS | TARGEGEN INC. (US) | 2009-04-09 | — | — | WO | disclosed |