Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR4 | P22455 | 17/20 | 0.51 |
| ▸ | FGFR1 | P11362 | 7/20 | 0.45 |
| ▸ | FGFR2 | P21802 | 7/20 | 0.45 |
| ▸ | FGFR3 | P22607 | 7/20 | 0.45 |
| ▸ | EGFR | P00533 | 6/20 | 0.45 |
| ▸ | KDR | P35968 | 5/20 | 0.45 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.45 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.45 |
| ▸ | FYN | P06241 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | EPHB3 | P54753 | 2/20 | 0.45 |
| ▸ | PRKACA | P17612 | 1/20 | 0.44 |
| ▸ | PRKACG | P22612 | 1/20 | 0.44 |
| ▸ | PRKACB | P22694 | 1/20 | 0.44 |
| ▸ | CSF1R | P07333 | 3/20 | 0.42 |
| ▸ | FLT1 | P17948 | 2/20 | 0.41 |
| ▸ | FLT4 | P35916 | 2/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | CSK | P41240 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4395788 | 0.87 | FGFR4 (0.44) | FGFR4FGFR1FGFR2FGFR3EGFR | |
| SCHEMBL4395906 | 0.87 | EGFR (0.43) | FGFR4FGFR1FGFR2FGFR3EGFR | |
| SCHEMBL3969871 | 0.86 | FGFR4 (0.52) | FGFR4FGFR1FGFR2FGFR3KDR | |
| SCHEMBL4404780 | 0.85 | FGFR1 (0.49) | FGFR4FGFR1FGFR2FGFR3 | |
| SCHEMBL5386534 | 0.84 | EGFR (0.44) | FGFR4FGFR1FGFR2FGFR3EGFR | |
| SCHEMBL3972876 | 0.83 | FGFR4 (0.49) | FGFR4FGFR1FGFR2FGFR3KDR | |
| SCHEMBL4410282 | 0.83 | FGFR1 (0.47) | FGFR4FGFR1FGFR2FGFR3EGFR | |
| SCHEMBL4403672 | 0.83 | EGFR (0.44) | FGFR4FGFR1FGFR2FGFR3EGFR | |
| SCHEMBL4550692 | 0.83 | EGFR (0.49) | FGFR4FGFR1FGFR2FGFR3EGFR | |
| SCHEMBL4403064 | 0.83 | FGFR4 (0.43) | FGFR4FGFR1FGFR2FGFR3EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7501425-B1 | Bicyclic pyrimidines and bicyclic 3,4-dihydropyprimidines as inhibitors of cellular proliferation | WARNER LAMBERT COMPANY (US) | 2009-03-10 | — | — | US | claimed |