Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | CYSLTR2 | Q9NS75 | 3/20 | 0.42 |
| ▸ | CYSLTR1 | Q9Y271 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3963466 | 0.85 | SMN1; SMN2 (0.46) | KDM4ESMN1; SMN2HPGD | |
| SCHEMBL2207238 | 0.85 | TDP1 (0.48) | — | |
| SCHEMBL15151046 | 0.83 | TDP1 (0.46) | KDM4EALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL27996046 | 0.83 | HPGD (0.51) | KDM4EALDH1A1LMNASMN1; SMN2MTNR1A | |
| SCHEMBL2209251 | 0.82 | PRSS1 (0.42) | ALDH1A1LMNASMN1; SMN2CYSLTR2CYSLTR1 | |
| SCHEMBL29818671 | 0.82 | PRSS1 (0.42) | ALDH1A1LMNASMN1; SMN2CYSLTR2CYSLTR1 | |
| SCHEMBL19291775 | 0.82 | PRSS1 (0.42) | ALDH1A1LMNASMN1; SMN2CYSLTR2CYSLTR1 | |
| SCHEMBL3704874 | 0.82 | CACNA1B (0.47) | KDM4EALDH1A1LMNASMN1; SMN2HPGD | |
| SCHEMBL2207665 | 0.81 | MAPK1 (0.43) | KDM4EALDH1A1LMNASMN1; SMN2CYSLTR2 | |
| SCHEMBL29818745 | 0.81 | MAPK1 (0.43) | KDM4EALDH1A1LMNASMN1; SMN2CYSLTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103553945-B | Alkoxy compounds for disease treatment | ACUCELA INC | 2015-01-07 | — | — | CN | disclosed |
| EP-2091955-A1 | ALKOXY COMPOUNDS FOR DISEASE TREATMENT | Acucela, Inc. (US) | 2009-08-26 | — | — | EP | disclosed |
| WO-2009045479-A1 | ALKOXY COMPOUNDS FOR DISEASE TREATMENT | ACUCELA INC. (US) | 2009-04-09 | — | — | WO | disclosed |