Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | ADRB2 | P07550 | 4/20 | 0.45 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.45 |
| ▸ | ADRB3 | P13945 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16149869 | 0.88 | KMT2A (0.55) | SMN1; SMN2KMT2A | |
| SCHEMBL2202484 | 0.87 | L3MBTL1 (0.44) | SMN1; SMN2HTTADRB2ADRB1ADRB3 | |
| SCHEMBL2207432 | 0.86 | BCHE (0.43) | SMN1; SMN2HTTADRB2ADRB1ADRB3 | |
| SCHEMBL29818987 | 0.85 | KMT2A (0.44) | SMN1; SMN2ADRB2ADRB1ADRB3KMT2A | |
| SCHEMBL3968993 | 0.85 | KDM4E (0.43) | SMN1; SMN2KDM4EHPGD | |
| SCHEMBL2208049 | 0.85 | KMT2A (0.44) | SMN1; SMN2ADRB2ADRB1ADRB3KMT2A | |
| SCHEMBL2778613 | 0.85 | ADRB2 (0.46) | SMN1; SMN2HTTADRB2ADRB1ADRB3 | |
| SCHEMBL29818773 | 0.84 | KMT2A (0.45) | SMN1; SMN2KMT2AMAPK1HPGD | |
| SCHEMBL2204281 | 0.84 | KMT2A (0.45) | SMN1; SMN2KMT2AMAPK1HPGD | |
| SCHEMBL27996240 | 0.83 | ADRB2 (0.45) | SMN1; SMN2HTTADRB2ADRB1ADRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2091955-A1 | ALKOXY COMPOUNDS FOR DISEASE TREATMENT | Acucela, Inc. (US) | 2009-08-26 | — | — | EP | disclosed |
| WO-2009045479-A1 | ALKOXY COMPOUNDS FOR DISEASE TREATMENT | ACUCELA INC. (US) | 2009-04-09 | — | — | WO | disclosed |