SCHEMBL3969306

SCHEMBL3969306

CN1CCN(c2ccc(N3CCCCC3)c(NC(=O)c3ccc(C#N)o3)c2)CC1

nearest known ligand 0.88

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CSF1R P07333 20/20 0.88
KIT P10721 1/20 0.64

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16050404 0.94 CSF1R (1.00) CSF1R
SCHEMBL31157967 0.92 CSF1R (1.00) CSF1RKIT
SCHEMBL31157983 0.92 CSF1R (1.00) CSF1RKIT
SCHEMBL13405631 0.92 CSF1R (1.00) CSF1RKIT
SCHEMBL13405637 0.89 CSF1R (0.90) CSF1R
SCHEMBL13148119 0.86 CSF1R (1.00) CSF1R
SCHEMBL13405636 0.86 CSF1R (0.75) CSF1R
SCHEMBL3965364 0.85 CSF1R (0.63) CSF1RKIT
SCHEMBL13405751 0.83 CSF1R (1.00) CSF1RKIT
SCHEMBL13180540 0.83 CSF1R (1.00) CSF1R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1807407-B1 AROMATIC AMIDES AS INHIBITORS OF C-FMS KINASE JANSSEN PHARMACEUTICA NV (BE) 2009-07-29 EP claimed
US-7705042-B2 Class of arylamide compounds useful as inhibitors of c-fms kinase JANSSEN PHARMACEUTICA NV (BE) 2010-04-27 US disclosed
US-7705042-B2 Class of arylamide compounds useful as inhibitors of c-fms kinase JANSSEN PHARMACEUTICA NV (BE) 2010-04-27 US disclosed