Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.71 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.71 |
| ▸ | ITGAV | P06756 | 7/20 | 0.64 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.57 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.57 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | ITGA2 | P17301 | 1/20 | 0.56 |
| ▸ | MMP1 | P03956 | 1/20 | 0.53 |
| ▸ | MMP2 | P08253 | 1/20 | 0.53 |
| ▸ | MMP3 | P08254 | 1/20 | 0.53 |
| ▸ | MMP7 | P09237 | 1/20 | 0.53 |
| ▸ | MMP9 | P14780 | 1/20 | 0.53 |
| ▸ | MMP13 | P45452 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3969631 | 1.00 | ALDH1A1 (0.71) | ALDH1A1CYP2C19ITGAVSLC1A3SLC1A2 | |
| SCHEMBL7434675 | 0.89 | ALDH1A1 (0.56) | ALDH1A1CYP2C19ITGAVSLC1A3SLC1A2 | |
| Phenanthroline SCHEMBL27798788 | 0.86 | CYP2C19 (0.56) | ALDH1A1CYP2C19ITGAVSLC1A3SLC1A2 | |
| SCHEMBL27692486 | 0.85 | ITGAV (0.67) | ALDH1A1CYP2C19ITGAVSLC1A3SLC1A2 | |
| SCHEMBL3898279 | 0.85 | ITGAV (0.67) | ALDH1A1CYP2C19ITGAVSLC1A3SLC1A2 | |
| SCHEMBL7064504 | 0.84 | POLB (0.60) | ALDH1A1CYP2C19ITGAVKDM4EMMP1 | |
| SCHEMBL7065916 | 0.84 | ALDH1A1 (0.59) | ALDH1A1CYP2C19ITGAVKDM4EMMP1 | |
| SCHEMBL6669839 | 0.84 | ITGAV (0.66) | ALDH1A1CYP2C19ITGAVSLC1A3SLC1A2 | |
| SCHEMBL6669846 | 0.84 | ITGAV (0.66) | ALDH1A1CYP2C19ITGAVSLC1A3SLC1A2 | |
| SCHEMBL7264756 | 0.84 | ALDH1A1 (0.52) | ALDH1A1CYP2C19ITGAVSLC1A3SLC1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030130251-A1 | Amino lactam sulfonamides as inhibitors of A-beta protein production | THOMPSON LORIN A (US) | 2003-07-10 | — | — | US | claimed |
| US-6503901-B1 | Alzheimer*s disease and Down*s syndrome treatment | BRISTOL MYERS SQUIBB PHARMA COMPANY | 2003-01-07 | — | — | US | claimed |
| EP-1218377-A1 | AMINO LACTAM SULFONAMIDES AS INHIBITORS OF A$g(b) PROTEIN PRODUCTION | Bristol-Myers Squibb Pharma Company (US) | 2002-07-03 | — | — | EP | claimed |
| WO-2001027108-A1 | AMINO LACTAM SULFONAMIDES AS INHIBITORS OF Aβ PROTEIN PRODUCTION | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2001-04-19 | — | — | WO | claimed |
| US-7579487-B2 | Process for making N-sulfonated-amino acid derivatives | MERCK & CO., INC. (US) | 2009-08-25 | — | — | US | disclosed |
| EP-1747212-A4 | PROCESS FOR MAKING N-SULFONATED-AMINO ACID DERIVATIVES | MERCK & CO INC (US) | 2009-03-25 | — | — | EP | disclosed |
| US-20070219382-A1 | Process For Making N-Sulfonated-Amino Acid Derivatives | MERCK SHARP & DOHME CORP. | 2007-09-20 | — | — | US | disclosed |
| EP-1747212-A2 | PROCESS FOR MAKING N-SULFONATED-AMINO ACID DERIVATIVES | Merck and Co., Inc. (US) | 2007-01-31 | — | — | EP | disclosed |
| WO-2005118529-A2 | PROCESS FOR MAKING N-SULFONATED-AMINO ACID DERIVATIVES | MERCK & CO., INC. (US) | 2005-12-15 | — | — | WO | disclosed |
| US-20030130251-A1 | Amino lactam sulfonamides as inhibitors of A-beta protein production | THOMPSON LORIN A (US) | 2003-07-10 | — | — | US | disclosed |
| US-6503901-B1 | Alzheimer*s disease and Down*s syndrome treatment | BRISTOL MYERS SQUIBB PHARMA COMPANY | 2003-01-07 | — | — | US | disclosed |
| EP-1222176-A1 | AMINO LACTAM SULFONAMIDES AS INHIBITORS OF A$g(b) PROTEIN PRODUCTION | Bristol-Myers Squibb Pharma Company (US) | 2002-07-17 | — | — | EP | disclosed |
| EP-1218377-A1 | AMINO LACTAM SULFONAMIDES AS INHIBITORS OF A$g(b) PROTEIN PRODUCTION | Bristol-Myers Squibb Pharma Company (US) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001027108-A1 | AMINO LACTAM SULFONAMIDES AS INHIBITORS OF Aβ PROTEIN PRODUCTION | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2001-04-19 | — | — | WO | disclosed |
| WO-2001027091-A1 | AMINO LACTAM SULFONAMIDES AS INHIBITORS OF Aβ PROTEIN PRODUCTION | DU PONT PHARMACEUTICALS COMPANY (US) | 2001-04-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070219382-A1 | Process For Making N-Sulfonated-Amino Acid Derivatives | ANTXR2, STS, ASNS | ALDH1A1 2796/4885CYP2C19 2175/4885ITGAV 2675/4885 |
| US-20030130251-A1 | Amino lactam sulfonamides as inhibitors of A-beta protein production | APP, APH1A, BACE1 | ALDH1A1 3364/4885CYP2C19 1907/4885ITGAV 4527/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.