SCHEMBL3969699

SCHEMBL3969699

O=C1NC(=O)C(Cc2cnc3cc(OCc4ccc(C(F)(F)F)cc4)ccc3c2)S1

nearest known ligand 0.60

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
FFAR1 O14842 11/20 0.60
MAOB P27338 2/20 0.53
PPARG P37231 6/20 0.52
PPARA Q07869 4/20 0.52
PTPN1 P18031 1/20 0.44
CYP3A4 P08684 1/20 0.43
RXRA P19793 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6958822 0.91 FFAR1 (0.52) FFAR1MAOBPPARGPPARACYP3A4
SCHEMBL6963885 0.88 FFAR1 (0.53) FFAR1MAOBPPARGPPARACYP3A4
SCHEMBL6964001 0.87 PPARG (0.56) FFAR1MAOBPPARGPPARACYP3A4
SCHEMBL377641 0.87 FFAR1 (0.59) FFAR1PPARGPPARACYP3A4
SCHEMBL29602962 0.87 FFAR1 (0.59) FFAR1PPARGPPARACYP3A4
SCHEMBL6958784 0.86 FFAR1 (0.58) FFAR1PPARGPPARACYP3A4RXRA
SCHEMBL6956120 0.86 FFAR1 (0.63) FFAR1PPARGPPARA
SCHEMBL6955421 0.84 FFAR1 (0.47) FFAR1PPARGPPARA
SCHEMBL6959296 0.84 FFAR1 (0.51) FFAR1MAOBPPARGPPARACYP3A4
SCHEMBL6964661 0.82 FFAR1 (0.51) FFAR1PPARGPPARACYP3A4RXRA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0787725-B1 QUINOLINE DERIVATIVE NIPPON CHEMIPHAR CO (JP) 2003-04-23 EP claimed
WO-2009043593-A1 COMBINATION THERAPY USING MEMANTINE AND GLITAZONES MERZ PHARMA GMBH & CO. KGAA (DE) 2009-04-09 WO disclosed
EP-0974348-B1 VISCERAL FAT LOWERING AGENT NIPPON CHEMIPHAR CO (JP) 2008-07-02 EP disclosed
EP-0787725-B1 QUINOLINE DERIVATIVE NIPPON CHEMIPHAR CO (JP) 2003-04-23 EP disclosed
US-6121288-A DECREASING VISCERAL FAT, INHIBITING ACCUMULATION OF VISCERAL FAT AND IMPROVING THE DISTRIBUTION OF VISCERAL FAT BY ADMINISTERING A 5-SUBSTITUTED-2,4-THIAZOLIDINEDIONE DERIVATIVE OF GIVEN FORMULA NIPPON CHEMIPHAR CO., LTD. (JP) 2000-09-19 US disclosed
EP-0974348-A1 VISCERAL FAT LOWERING AGENT NIPPON CHEMIPHAR CO., LTD. (JP) 2000-01-26 EP disclosed
EP-0787725-A1 QUINOLINE DERIVATIVE NIPPON CHEMIPHAR CO., LTD. (JP) 1997-08-06 EP disclosed