Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.43 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CRHBP | P24387 | 1/20 | 0.39 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1466714 | 0.85 | ALDH1A1 (0.48) | ALDH1A1TRIM24TRIM33CYP3A4CYP2C9 | |
| SCHEMBL5553590 | 0.84 | ALDH1A1 (0.67) | ALDH1A1TRIM24TRIM33CYP3A4CYP2C9 | |
| SCHEMBL1465884 | 0.84 | ALDH1A1 (0.59) | ALDH1A1TRIM24TRIM33CYP3A4CYP2C9 | |
| SCHEMBL6766311 | 0.84 | TRIM24 (0.51) | ALDH1A1TRIM24TRIM33CYP3A4CYP2C9 | |
| SCHEMBL21609586 | 0.75 | ALDH1A1 (0.44) | ALDH1A1CYP3A4CYP2C9CYP2C19KDM4E | |
| SCHEMBL31395309 | 0.75 | ALDH1A1 (0.44) | ALDH1A1CYP3A4CYP2C9CYP2C19KDM4E | |
| SCHEMBL1466237 | 0.73 | MEN1 (0.43) | ALDH1A1TRIM24TRIM33HPGDKMT2A | |
| SCHEMBL27881516 | 0.72 | MEN1 (0.74) | ALDH1A1CYP2C9CYP2C19KDM4ECYP1A2 | |
| SCHEMBL1255150 | 0.72 | TRIM24 (0.52) | ALDH1A1TRIM24TRIM33KDM4EHPGD | |
| SCHEMBL3719104 | 0.71 | POLB (0.48) | ALDH1A1TRIM24TRIM33CYP2C19CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108341799-B | Novel indole derivatives for the treatment of cancer, viral infections and lung diseases | 生物控制术公司 | 2022-01-25 | — | — | CN | disclosed |
| US-10851054-B2 | Derivatives of indole for the treatment of cancer, viral infections and lung diseases | BIOKINESIS (FR) | 2020-12-01 | — | — | US | disclosed |
| US-20190169124-A1 | NEW DERIVATIVES OF INDOLE FOR THE TREATMENT OF CANCER, VIRAL INFECTIONS AND LUNG DISEASES | DIACCURATE (FR) | 2019-06-06 | — | — | US | disclosed |
| US-10189782-B2 | Derivatives of indole for the treatment of cancer, viral infections and lung diseases | BIOKINESIS (FR) | 2019-01-29 | — | — | US | disclosed |
| CN-108341799-A | For treating cancer, the novel indole derivative of virus infection and tuberculosis | 生物控制术公司 | 2018-07-31 | — | — | CN | disclosed |
| CN-104854088-B | Novel indole derivatives for the treatment of cancer, viral infections and lung diseases | 生物控制术公司 | 2018-02-16 | — | — | CN | disclosed |
| US-20170233342-A1 | NEW DERIVATIVES OF INDOLE FOR THE TREATMENT OF CANCER, VIRAL INFECTIONS AND LUNG DISEASES | DIACCURATE (FR) | 2017-08-17 | — | — | US | disclosed |
| US-9643923-B2 | Derivatives of indole for the treatment of cancer, viral infections and lung diseases | BIOKINESIS (FR) | 2017-05-09 | — | — | US | disclosed |
| US-20150307450-A1 | NEW DERIVATIVES OF INDOLE FOR THE TREATMENT OF CANCER, VIRAL INFECTIONS AND LUNG DISEASES | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2015-10-29 | — | — | US | disclosed |
| CN-104854088-A | Novel indole derivatives for the treatment of cancer, viral infections and lung diseases | BIOKINESIS | 2015-08-19 | — | — | CN | disclosed |
| WO-2009044147-A1 | INDOLIZINE DERIVATIVES WITH CRTH2 RECEPTOR AFFINITY FOR THE TREATMENT OF INFLAMMATORY DISEASES | ARGENTA DISCOVERY LIMITED (GB) | 2009-04-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190169124-A1 | NEW DERIVATIVES OF INDOLE FOR THE TREATMENT OF CANCER, VIRAL INFECTIONS AND LUNG DISEASES | IDO2, IDO1, ING2 | ALDH1A1 2891/4885TRIM24 258/4885TRIM33 685/4885 |
| US-20150307450-A1 | NEW DERIVATIVES OF INDOLE FOR THE TREATMENT OF CANCER, VIRAL INFECTIONS AND LUNG DISEASES | IDO2, IDO1, ING2 | ALDH1A1 2891/4885TRIM24 258/4885TRIM33 685/4885 |
| US-10189782-B2 | Derivatives of indole for the treatment of cancer, viral infections and lung diseases | IDO2, IDO1, ING2 | ALDH1A1 2533/4885TRIM24 201/4885TRIM33 542/4885 |
| US-20170233342-A1 | NEW DERIVATIVES OF INDOLE FOR THE TREATMENT OF CANCER, VIRAL INFECTIONS AND LUNG DISEASES | IDO2, IDO1, ING2 | ALDH1A1 2891/4885TRIM24 258/4885TRIM33 685/4885 |
| US-10851054-B2 | Derivatives of indole for the treatment of cancer, viral infections and lung diseases | IDO2, IDO1, ING2 | ALDH1A1 2533/4885TRIM24 201/4885TRIM33 542/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.