Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 18/20 | 0.54 |
| ▸ | PGR | P06401 | 5/20 | 0.54 |
| ▸ | NR3C2 | P08235 | 3/20 | 0.47 |
| ▸ | AR | P10275 | 3/20 | 0.47 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.36 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3970484 | 0.93 | NR3C1 (0.55) | NR3C1PGRNR3C2ARTAS2R14 | |
| SCHEMBL3963416 | 0.91 | NR3C1 (0.57) | NR3C1PGRNR3C2ARTAS2R14 | |
| SCHEMBL3960392 | 0.90 | NR3C1 (0.54) | NR3C1PGRNR3C2ARTAS2R14 | |
| SCHEMBL3968059 | 0.90 | NR3C1 (0.57) | NR3C1PGRNR3C2ARTAS2R14 | |
| SCHEMBL3967760 | 0.88 | NR3C1 (0.54) | NR3C1PGRNR3C2ARTAS2R14 | |
| SCHEMBL3966697 | 0.87 | NR3C1 (0.50) | NR3C1PGRNR3C2ARTAS2R14 | |
| SCHEMBL3968296 | 0.87 | NR3C1 (0.46) | NR3C1PGRNR3C2AR | |
| SCHEMBL3963221 | 0.87 | NR3C1 (0.72) | NR3C1PGRNR3C2AR | |
| SCHEMBL3963218 | 0.87 | NR3C1 (0.72) | NR3C1PGRNR3C2AR | |
| SCHEMBL3967049 | 0.87 | NR3C1 (0.53) | NR3C1PGRNR3C2ARTAS2R14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1363876-B1 | GLUCOCORTICOID RECEPTOR MODULATORS | KAROBIO AB (SE) | 2009-07-29 | — | — | EP | disclosed |
| EP-1363876-A1 | GLUCOCORTICOID RECEPTOR MODULATORS | Abbott Laboratories (US) | 2003-11-26 | — | — | EP | disclosed |
| US-6583180-B2 | Antidiabetic agents | ABBOTT LABORATORIES | 2003-06-24 | — | — | US | disclosed |
| WO-2002064550-A1 | GLUCOCORTICOID RECEPTOR MODULATORS | ABBOTT LABORATORIES (US) | 2002-08-22 | — | — | WO | disclosed |