Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR4 | P22455 | 9/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 8/20 | 0.41 |
| ▸ | FGFR2 | P21802 | 5/20 | 0.41 |
| ▸ | FGFR3 | P22607 | 5/20 | 0.41 |
| ▸ | LCK | P06239 | 2/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.39 |
| ▸ | KDR | P35968 | 3/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | CDK4 | P11802 | 1/20 | 0.38 |
| ▸ | CCND1 | P24385 | 1/20 | 0.38 |
| ▸ | CCND2 | P30279 | 1/20 | 0.38 |
| ▸ | CCND3 | P30281 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | BCR | P11274 | 1/20 | 0.37 |
| ▸ | FYN | P06241 | 2/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | CSF1R | P07333 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3972198 | 0.94 | LCK (0.46) | FGFR4FGFR1FGFR2FGFR3LCK | |
| SCHEMBL3971394 | 0.88 | FGFR4 (0.40) | FGFR4FGFR1FGFR2FGFR3KDR | |
| SCHEMBL3967320 | 0.86 | FGFR1 (0.49) | FGFR4FGFR1FGFR2FGFR3LCK | |
| SCHEMBL3972449 | 0.83 | LCK (0.47) | FGFR4FGFR1FGFR2FGFR3LCK | |
| SCHEMBL3975148 | 0.80 | FGFR1 (0.50) | FGFR4FGFR1FGFR2FGFR3KDR | |
| SCHEMBL3971288 | 0.78 | FGFR4 (0.39) | FGFR4FGFR1FGFR2FGFR3LCK | |
| SCHEMBL3973163 | 0.76 | FGFR4 (0.47) | FGFR4FGFR1FGFR2FGFR3KDR | |
| SCHEMBL7850396 | 0.75 | FGFR3 (0.39) | FGFR4FGFR1FGFR2FGFR3KDR | |
| SCHEMBL3975943 | 0.74 | FGFR4 (0.51) | FGFR4FGFR1FGFR2FGFR3LCK | |
| SCHEMBL3972049 | 0.74 | LCK (0.53) | FGFR4FGFR1FGFR2FGFR3LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7501425-B1 | Bicyclic pyrimidines and bicyclic 3,4-dihydropyprimidines as inhibitors of cellular proliferation | WARNER LAMBERT COMPANY (US) | 2009-03-10 | — | — | US | claimed |