Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR3 | P22607 | 4/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.37 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.37 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | FGFR4 | P22455 | 4/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7840386 | 0.88 | MAPK1 (0.43) | FGFR3FGFR1FGFR2KDRPIK3CA | |
| SCHEMBL3971394 | 0.86 | FGFR4 (0.40) | FGFR3FGFR1FGFR2KDRPIK3CA | |
| SCHEMBL3975643 | 0.76 | FGFR1 (0.49) | FGFR3FGFR1FGFR2KDRFGFR4 | |
| SCHEMBL3971288 | 0.76 | FGFR4 (0.39) | FGFR3FGFR1FGFR2KDRFGFR4 | |
| SCHEMBL3970098 | 0.75 | FGFR4 (0.41) | FGFR3FGFR1FGFR2KDRFGFR4 | |
| SCHEMBL3972198 | 0.74 | LCK (0.46) | FGFR3FGFR1FGFR2KDRMAPK8 | |
| SCHEMBL3973163 | 0.73 | FGFR4 (0.47) | FGFR3FGFR1FGFR2KDRPIK3CA | |
| SCHEMBL3975148 | 0.70 | FGFR1 (0.50) | FGFR3FGFR1FGFR2KDRFGFR4 | |
| SCHEMBL3970864 | 0.70 | FGFR1 (0.49) | FGFR3FGFR1FGFR2KDRFGFR4 | |
| SCHEMBL3968638 | 0.69 | FGFR4 (0.53) | FGFR3FGFR1FGFR2KDRFGFR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1080092-A2 | BICYCLIC PYRIMIDINES AND BICYCLIC 3,4-DIHYDROPYRIMIDINES AS INHIBITORS OF CELLULAR PROLIFERATION | WARNER-LAMBERT COMPANY (US) | 2001-03-07 | — | — | EP | claimed |
| WO-1999061444-A2 | BICYCLIC PYRIMIDINES AND BICYCLIC 3,4-DIHYDROPYRIMIDINES AS INHIBITORS OF CELLULAR PROLIFERATION | WARNER-LAMBERT COMPANY (US) | 1999-12-02 | — | — | WO | claimed |