Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SSTR5 | P35346 | 7/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.34 |
| ▸ | TACR1 | P25103 | 4/20 | 0.34 |
| ▸ | HTR2A | P28223 | 2/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.32 |
| ▸ | MC4R | P32245 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3972867 | 0.93 | SSTR5 (0.35) | SSTR5KCNH2TACR1SLC6A2SLC6A4 | |
| SCHEMBL3978900 | 0.89 | SSTR5 (0.44) | SSTR5KCNH2 | |
| SCHEMBL3971319 | 0.89 | REN (0.42) | KCNH2TACR1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL3937177 | 0.86 | TACR1 (0.35) | SSTR5KCNH2TACR1HTR2ASLC6A2 | |
| SCHEMBL3973182 | 0.84 | SSTR5 (0.38) | SSTR5KCNH2TACR1SLC6A2SLC6A4 | |
| SCHEMBL3970171 | 0.81 | HTR2A (0.36) | SSTR5KCNH2TACR1HTR2ASLC6A2 | |
| SCHEMBL3978569 | 0.81 | SSTR5 (0.45) | SSTR5KCNH2 | |
| SCHEMBL3972445 | 0.79 | SSTR5 (0.40) | SSTR5KCNH2TACR1HTR2ASLC6A2 | |
| SCHEMBL4705309 | 0.79 | SLC6A2 (0.41) | SSTR5KCNH2TACR1HTR2ASLC6A2 | |
| SCHEMBL3973958 | 0.78 | SSTR5 (0.40) | SSTR5KCNH2TACR1HTR2ASLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2054385-A2 | PHENYL, PYRIDINE AND QUINOLINE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2009-05-06 | — | — | EP | claimed |
| WO-2008019967-A2 | PHENYL, PYRIDINE AND QUINOLINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-02-21 | — | — | WO | claimed |
| EP-2054385-A2 | PHENYL, PYRIDINE AND QUINOLINE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2009-05-06 | — | — | EP | disclosed |
| WO-2008019967-A2 | PHENYL, PYRIDINE AND QUINOLINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-02-21 | — | — | WO | disclosed |