Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Calcitriol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VDR known ✓ | P11473 | 10/20 | 1.00 |
| ▸ | MAPT | P10636 | 3/20 | 1.00 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 1.00 |
| ▸ | SLC6A2 | P23975 | 2/20 | 1.00 |
| ▸ | AGTR1 | P30556 | 2/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 1.00 |
| ▸ | NR1I2 | O75469 | 1/20 | 1.00 |
| ▸ | ABCB11 | O95342 | 1/20 | 1.00 |
| ▸ | GC | P02774 | 1/20 | 1.00 |
| ▸ | PGR | P06401 | 1/20 | 1.00 |
| ▸ | RXRA | P19793 | 1/20 | 1.00 |
| ▸ | CHRM3 | P20309 | 1/20 | 1.00 |
| ▸ | CNR1 | P21554 | 1/20 | 1.00 |
| ▸ | HTR2C | P28335 | 1/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 1/20 | 1.00 |
| ▸ | SLC6A4 | P31645 | 1/20 | 1.00 |
| ▸ | ADRA1A | P35348 | 1/20 | 1.00 |
| ▸ | PTGS2 | P35354 | 1/20 | 1.00 |
| ▸ | OPRD1 | P41143 | 1/20 | 1.00 |
| ▸ | OPRK1 | P41145 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Calcitriol SCHEMBL13749608 | 1.00 | VDR (1.00) | VDRMAPTADORA3SLC6A2AGTR1 | |
| Calcitriol SCHEMBL39703 | 1.00 | VDR (1.00) | VDRMAPTADORA3SLC6A2AGTR1 | |
| Calcitriol SCHEMBL2867274 | 1.00 | VDR (1.00) | VDRMAPTADORA3SLC6A2AGTR1 | |
| Calcitriol SCHEMBL93587 | 1.00 | VDR (1.00) | VDRMAPTADORA3SLC6A2AGTR1 | |
| Calcitriol SCHEMBL24066838 | 1.00 | VDR (1.00) | VDRMAPTADORA3SLC6A2AGTR1 | |
| Calcitriol SCHEMBL9048511 | 1.00 | VDR (1.00) | VDRMAPTADORA3SLC6A2AGTR1 | |
| Calcitriol SCHEMBL23386523 | 1.00 | VDR (1.00) | VDRMAPTADORA3SLC6A2AGTR1 | |
| Calcitriol SCHEMBL10034115 | 1.00 | VDR (1.00) | VDRMAPTADORA3SLC6A2AGTR1 | |
| Calcitriol SCHEMBL7115065 | 1.00 | VDR (1.00) | VDRMAPTADORA3SLC6A2AGTR1 | |
| Calcitriol SCHEMBL21055106 | 1.00 | VDR (1.00) | VDRMAPTADORA3SLC6A2AGTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 7789 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260034149-A1 | ENHANCED SALICYLIC ACID AND DRUG DELIVERY FOR AQUEOUS TOPICAL APPLICATIONS | Otiko, Christopher Ayo (US) | 2026-02-05 | — | — | US | claimed |
| EP-4647447-A2 | BINDING PARTNERS SPECIFIC FOR VITAMIN D EPIMERS | Siemens Healthcare Diagnostics, Inc. (US) | 2025-11-12 | — | — | EP | claimed |
| US-12465567-B2 | Enhanced antibiotic and drug delivery for aqueous topical applications for human and veterinary uses | Otiko, Christopher Ayo (US) | 2025-11-11 | — | — | US | claimed |
| US-20250228874-A1 | CALCITRIOL OR CALCITRIOL ANALOGUES FOR TREATING PERIPERHAL NEUROPATHIC PAIN DISORDERS | EPTIVA THERAPEUTICS LTD. (GB) | 2025-07-17 | — | — | US | claimed |
| US-12343421-B2 | Vitamin D base layer | Solaana MD LLC (US) | 2025-07-01 | — | — | US | claimed |
| EP-4573188-A1 | OXIDATION OF STEROIDS | Oxford University Innovation Limited (GB) | 2025-06-25 | — | — | EP | claimed |
| WO-2025108575-A1 | METHODS OF SELECTIVE DEPROTECTION AND SYNTHESIS OF TRANSHYDRINDANE- SKELETON-BASED COMPOUNDS | ROCHE DIAGNOSTICS GMBH (DE) | 2025-05-30 | — | — | WO | claimed |
| US-20240392280-A1 | PRODUCTS AND METHODS FOR ASSESSING AND INCREASING KLOTHO PROTEIN LEVELS | KLOTHO THERAPEUTICS, INC. | 2024-11-28 | — | — | US | claimed |
| CN-116369527-B | Bifidobacterium breve capable of regulating bone development and application thereof | 江南大学 | 2024-07-30 | — | — | CN | claimed |
| EP-4379384-A2 | COMPOSITIONS, DEVICES, AND METHODS OF MITIGATING LIPOPROTEIN INTERFERENCE IN IN VITRO DIAGNOSTIC ASSAYS FOR HYDROPHOBIC ANALYTES | Siemens Healthcare Diagnostics Inc. (US) | 2024-06-05 | — | — | EP | claimed |
| WO-1990006121-A2 | METHOD FOR IMPROVING REPRODUCTIVE FUNCTIONS IN MAMMALS | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 1990-06-14 | — | — | WO | claimed |
| EP-0301167-A1 | A combination of cholecalciferol derivatives for the treatment of renal bone disease | Teva Pharmaceutical Industries Limited (IL) | 1989-02-01 | — | — | EP | claimed |
| EP-0202276-A4 | COMPOSITION FOR THE TREATMENT OF PSORIASIS. | GEN HOSPITAL CORP (US) | 1988-09-28 | — | — | EP | claimed |
| EP-0202276-A1 | COMPOSITION FOR THE TREATMENT OF PSORIASIS. | GEN HOSPITAL CORP (US) | 1986-11-26 | — | — | EP | claimed |
| WO-1986002527-A1 | METHOD OF TREATING PSORIASIS | THE GENERAL HOSPITAL CORPORATION (US) | 1986-05-09 | — | — | WO | claimed |
| EP-0042673-B1 | CYTORECEPTOR ASSAY | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1986-03-26 | — | — | EP | claimed |
| EP-0042673-A1 | Cytoreceptor assay | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1981-12-30 | — | — | EP | claimed |
| US-4225596-A | Method for treating calcium imbalance and improving calcium absorption in mammals | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 1980-09-30 | — | — | US | claimed |
| US-4110446-A | METHOD OF TREATING MILK FEVER IN DAIRY CATTLE WITH 1,25-DIHYDROXYCHOLECALCIFEROL | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 1978-08-29 | — | — | US | claimed |
| US-4035493-A | Rodenticide | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 1977-07-12 | — | — | US | claimed |