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SCHEMBL3971179

SCHEMBL3971179

Cc1noc(C)c1-c1ccc(C2(C(=O)N3CCC4(C3)OC(=O)c3ccccc34)CC2)cc1.Cn1cc(-c2ccc(C3(C(=O)N4CCC5(C4)OC(=O)c4ccccc45)CC3)cc2)cn1

nearest known ligand 0.62

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
▸ HSD11B1 P28845 17/20 0.62
▸ CYP2D6 P10635 1/20 0.56
▸ NPY5R Q15761 3/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL348974 0.92 HSD11B1 (0.69) HSD11B1CYP2D6NPY5R
SCHEMBL349658 0.92 HSD11B1 (0.69) HSD11B1CYP2D6NPY5R
SCHEMBL350633 0.91 HSD11B1 (0.75) HSD11B1CYP2D6NPY5R
SCHEMBL348718 0.91 HSD11B1 (0.75) HSD11B1CYP2D6NPY5R
SCHEMBL350426 0.81 HSD11B1 (0.80) HSD11B1CYP2D6NPY5R
SCHEMBL350497 0.81 HSD11B1 (0.80) HSD11B1CYP2D6NPY5R
SCHEMBL350400 0.78 HSD11B1 (0.82) HSD11B1CYP2D6NPY5R
SCHEMBL349927 0.78 HSD11B1 (0.82) HSD11B1CYP2D6NPY5R
SCHEMBL350720 0.77 HSD11B1 (1.00) HSD11B1CYP2D6NPY5R
SCHEMBL348579 0.77 HSD11B1 (1.00) HSD11B1CYP2D6NPY5R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1756063-A4 AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS INCYTE CORP (US) 2009-03-25 — — EP claimed
EP-1756063-A1 AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS Incyte Corporation (US) 2007-02-28 — — EP claimed
WO-2005110992-A1 AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS INCYTE CORPORATION (US) 2005-11-24 — — WO claimed