Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 17/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.37 |
| ▸ | ADAMTS7 | Q9UKP4 | 1/20 | 0.37 |
| ▸ | MMP1 | P03956 | 2/20 | 0.35 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.35 |
| ▸ | TNF | P01375 | 1/20 | 0.35 |
| ▸ | MMP2 | P08253 | 1/20 | 0.35 |
| ▸ | MMP3 | P08254 | 1/20 | 0.35 |
| ▸ | MMP9 | P14780 | 1/20 | 0.35 |
| ▸ | MMP8 | P22894 | 1/20 | 0.35 |
| ▸ | MMP13 | P45452 | 1/20 | 0.35 |
| ▸ | MMP14 | P50281 | 1/20 | 0.35 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.35 |
| ▸ | ADAMTS1 | Q9UHI8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL348509 | 0.94 | HSD11B1 (0.62) | HSD11B1CYP2D6 | |
| SCHEMBL351129 | 0.94 | HSD11B1 (0.66) | HSD11B1CYP2D6ADAMTS5ADAMTS7 | |
| SCHEMBL350735 | 0.85 | HSD11B1 (0.66) | HSD11B1CYP2D6 | |
| SCHEMBL351068 | 0.84 | HSD11B1 (0.60) | HSD11B1CYP2D6 | |
| SCHEMBL351069 | 0.84 | HSD11B1 (0.60) | HSD11B1CYP2D6 | |
| SCHEMBL351116 | 0.82 | HSD11B1 (0.67) | HSD11B1CYP2D6 | |
| SCHEMBL3969697 | 0.82 | HSD11B1 (0.67) | HSD11B1CYP2D6 | |
| SCHEMBL3972417 | 0.82 | HSD11B1 (0.64) | HSD11B1CYP2D6 | |
| SCHEMBL349451 | 0.82 | HSD11B1 (0.64) | HSD11B1CYP2D6 | |
| SCHEMBL349161 | 0.79 | HSD11B1 (0.71) | HSD11B1CYP2D6ADAM17 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756063-A4 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORP (US) | 2009-03-25 | — | — | EP | claimed |
| EP-1756063-A1 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | Incyte Corporation (US) | 2007-02-28 | — | — | EP | claimed |
| WO-2005110992-A1 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORPORATION (US) | 2005-11-24 | — | — | WO | claimed |