Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | PNMT | P11086 | 1/20 | 0.37 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | PPARA | Q07869 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.33 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.33 |
| ▸ | IGF1R | P08069 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2173678 | 0.88 | MAPT (0.39) | MAPTALDH1A1PNMTTAAR1MAPK1 | |
| SCHEMBL3978582 | 0.88 | MAPT (0.47) | MAPTKDM4EALDH1A1ALOX5GAA | |
| SCHEMBL1568015 | 0.80 | PNMT (0.41) | MAPTPNMTTAAR1MAPK1KCNH2 | |
| SCHEMBL3973326 | 0.79 | MAPT (0.39) | MAPTKDM4EALDH1A1ALOX5GAA | |
| SCHEMBL1568422 | 0.78 | IGF1R (0.44) | MAPTPNMTTAAR1MAPK1SIGMAR1 | |
| SCHEMBL28920633 | 0.73 | PPARG (0.38) | MAPTMAPK1KCNH2PPARGPPARA | |
| SCHEMBL2172166 | 0.73 | PIK3CA (0.45) | MAPTALDH1A1PNMTTAAR1ALOX15 | |
| SCHEMBL3264645 | 0.73 | MAPT (0.47) | MAPTKDM4EALDH1A1ALOX5GAA | |
| SCHEMBL14656091 | 0.73 | HTR2A (0.47) | MAPTALDH1A1KCNH2PPARGPPARA | |
| SCHEMBL2092848 | 0.73 | MAPT (0.45) | MAPTPNMTTAAR1MAPK1PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2054410-A2 | OXAZOLIDONE DERIVATIVES AS PR MODULATORS | Wyeth (US) | 2009-05-06 | — | — | EP | disclosed |
| WO-2008021331-A2 | OXAZOLIDONE DERIVATIVES AS PR MODULATORS | WYETH (US) | 2008-02-21 | — | — | WO | disclosed |