Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SSTR5 | P35346 | 9/20 | 0.46 |
| ▸ | HRH1 | P35367 | 2/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3973186 | 0.84 | SSTR5 (0.49) | SSTR5HRH1HTR2BMAPK1HSD17B10 | |
| SCHEMBL2422484 | 0.80 | SSTR5 (0.47) | SSTR5HRH1HTR2BACHE | |
| SCHEMBL2419838 | 0.80 | SSTR5 (0.59) | SSTR5HRH1HTR2BACHE | |
| SCHEMBL3977626 | 0.79 | SSTR5 (0.49) | SSTR5HRH1HTR2BDRD2DRD4 | |
| SCHEMBL4702165 | 0.77 | SSTR5 (0.46) | SSTR5HRH1HTR2BMAPK1HSD17B10 | |
| SCHEMBL3937223 | 0.77 | SSTR5 (0.48) | SSTR5HRH1HTR2BDRD2DRD4 | |
| SCHEMBL2417184 | 0.76 | SSTR5 (0.54) | SSTR5HRH1HTR2BACHE | |
| SCHEMBL3977762 | 0.75 | SSTR5 (0.52) | SSTR5HRH1HTR2BMAPK1HSD17B10 | |
| SCHEMBL4002561 | 0.74 | DRD2 (0.45) | SSTR5HRH1HTR2BDRD2MEN1 | |
| SCHEMBL2420626 | 0.73 | SSTR5 (0.58) | SSTR5HRH1HTR2BACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2054385-A2 | PHENYL, PYRIDINE AND QUINOLINE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2009-05-06 | — | — | EP | claimed |
| WO-2008019967-A2 | PHENYL, PYRIDINE AND QUINOLINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-02-21 | — | — | WO | claimed |