Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | PPARA | Q07869 | 2/20 | 0.45 |
| ▸ | PPARG | P37231 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | MMP13 | P45452 | 1/20 | 0.43 |
| ▸ | CYSLTR2 | Q9NS75 | 2/20 | 0.42 |
| ▸ | CYSLTR1 | Q9Y271 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.40 |
| ▸ | LTA4H | P09960 | 1/20 | 0.40 |
| ▸ | CTSS | P25774 | 1/20 | 0.40 |
| ▸ | CTSK | P43235 | 1/20 | 0.40 |
| ▸ | FAAH | O00519 | 1/20 | 0.40 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.40 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.40 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3971815 | 0.88 | PTGDR2 (0.43) | PPARAPPARGMMP13CYP2D6CTSS | |
| SCHEMBL4572153 | 0.83 | PPARA (0.50) | PPARAPPARGMMP13CYSLTR2CYSLTR1 | |
| SCHEMBL12432984 | 0.77 | CYSLTR2 (0.50) | MMP13CYSLTR2CYSLTR1LTA4HFAAH | |
| SCHEMBL19363215 | 0.77 | EPHX2 (0.51) | TSHRCYSLTR2CYSLTR1FAAHPDK2 | |
| SCHEMBL2208832 | 0.77 | PFKFB3 (0.42) | MAPK1L3MBTL1TSHRTDP1MMP13 | |
| SCHEMBL29823058 | 0.77 | PFKFB3 (0.45) | MAPK1L3MBTL1CYSLTR2CYSLTR1CTSK | |
| SCHEMBL5353383 | 0.76 | CYP1A2 (0.49) | L3MBTL1CYP2D6CTSK | |
| SCHEMBL3159659 | 0.76 | PPARA (0.60) | MAPK1L3MBTL1PPARAPPARGTSHR | |
| SCHEMBL2137203 | 0.75 | MAPK1 (0.66) | MAPK1L3MBTL1PPARAPPARGTSHR | |
| SCHEMBL4572152 | 0.74 | PPARA (0.59) | MAPK1L3MBTL1PPARAPPARGTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2091955-A1 | ALKOXY COMPOUNDS FOR DISEASE TREATMENT | Acucela, Inc. (US) | 2009-08-26 | — | — | EP | disclosed |
| WO-2009045479-A1 | ALKOXY COMPOUNDS FOR DISEASE TREATMENT | ACUCELA INC. (US) | 2009-04-09 | — | — | WO | disclosed |