Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 4/20 | 0.38 |
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | SLC22A4 | Q9H015 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | GFER | P55789 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30231281 | 0.75 | ESR1 (0.47) | DAOGAAALDH1A1ESR1ESR2 | |
| SCHEMBL6547407 | 0.75 | ESR1 (0.47) | DAOGAAALDH1A1ESR1ESR2 | |
| SCHEMBL29128215 | 0.73 | ALDH1A1 (0.49) | GAASLC22A4ALDH1A1HTTMAPT | |
| SCHEMBL8072431 | 0.71 | ESR1 (0.44) | DAOGAAALDH1A1ESR1ESR2 | |
| SCHEMBL3752945 | 0.71 | EED (0.39) | DAOHTR2A | |
| SCHEMBL2474964 | 0.70 | CYP19A1 (0.52) | ALDH1A1MAPT | |
| SCHEMBL11855414 | 0.68 | ESR1 (0.42) | GAAALDH1A1ESR1ESR2MAPT | |
| SCHEMBL29407427 | 0.67 | ESR1 (0.44) | DAOGAAALDH1A1ESR1ESR2 | |
| SCHEMBL599914 | 0.67 | ESR1 (0.44) | DAOGAAALDH1A1ESR1ESR2 | |
| SCHEMBL24477895 | 0.67 | TAAR1 (0.50) | DAOGPR84GAAALDH1A1ESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3813793-A1 | A COMPOSITION FOR TREATING OCULAR HYPEREMIA AND A METHOD FOR TREATING OCULAR HYPEREMIA WITH THE SAME | Cloudbreak Therapeutics, LLC (US) | 2021-05-05 | — | — | EP | disclosed |
| EP-3038610-A1 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF PRESBYOPIA | Presbyopia Therapies, LLC (US) | 2016-07-06 | — | — | EP | disclosed |
| WO-2015031186-A1 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF PRESBYOPIA | PRESBYOPIA THERAPLIES, LLC (US) | 2015-03-05 | — | — | WO | disclosed |
| WO-2009052072-A1 | TREATING MOTOR DISORDERS WITH 4-(1-(2,3-DIMETHYLPHENYL)ETHYL)-1H-IMIDAZOLE-2(3H)-THIONE | ALLERGAN, INC. (US) | 2009-04-23 | — | — | WO | disclosed |