SCHEMBL3972822

CS(=O)(=O)c1ccc(-c2ccc(C3(C(=O)N4CCC5(C4)OC(=O)c4cnccc45)CC3)cn2)cc1.Cn1ccc2cc(-c3ccc(C4(C(=O)N5CCC6(C5)OC(=O)c5cnccc56)CC4)cn3)ccc21

nearest known ligand 0.55

Predicted protein targets (top 5)

	gene	UniProt	supporting neighbours	confidence
▸	HSD11B1	P28845	17/20	0.55

▸	CYP2D6	P10635	1/20	0.40

▸	CCNC	P24863	2/20	0.37

▸	CDK8	P49336	2/20	0.37

▸	NPY5R	Q15761	1/20	0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL351411	0.94	HSD11B1 (0.60)	HSD11B1CYP2D6CCNCCDK8
SCHEMBL349038	0.94	HSD11B1 (0.60)	HSD11B1CYP2D6CCNCCDK8
SCHEMBL350491	0.91	HSD11B1 (0.67)	HSD11B1CYP2D6NPY5R
SCHEMBL349586	0.91	HSD11B1 (0.67)	HSD11B1CYP2D6NPY5R
SCHEMBL370771	0.86	HSD11B1 (0.72)	HSD11B1CYP2D6NPY5R
SCHEMBL350221	0.86	HSD11B1 (0.72)	HSD11B1CYP2D6NPY5R
SCHEMBL347974	0.82	HSD11B1 (0.81)	HSD11B1CYP2D6NPY5R
SCHEMBL351160	0.82	HSD11B1 (0.81)	HSD11B1CYP2D6NPY5R
SCHEMBL349487	0.81	HSD11B1 (0.83)	HSD11B1CYP2D6NPY5R
SCHEMBL351109	0.80	HSD11B1 (0.82)	HSD11B1CYP2D6NPY5R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-1756063-A4	AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS	INCYTE CORP (US)	2009-03-25	—	—	EP	claimed
EP-1756063-A1	AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS	Incyte Corporation (US)	2007-02-28	—	—	EP	claimed
WO-2005110992-A1	AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS	INCYTE CORPORATION (US)	2005-11-24	—	—	WO	claimed