Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC2A1 | P11166 | 1/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.45 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.45 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.44 |
| ▸ | PARP10 | Q53GL7 | 3/20 | 0.44 |
| ▸ | PARP15 | Q460N3 | 2/20 | 0.44 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.44 |
| ▸ | TLR4 | O00206 | 1/20 | 0.43 |
| ▸ | TLR2 | O60603 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3970375 | 0.99 | FFAR4 (0.45) | SLC2A1FFAR1FFAR4SIRT2PARP10 | |
| SCHEMBL2207367 | 0.86 | SLC2A1 (0.42) | SLC2A1FFAR1FFAR4SIRT2PARP10 | |
| SCHEMBL2209469 | 0.84 | SLC2A1 (0.41) | SLC2A1FFAR4SIRT2PARP10PARP15 | |
| SCHEMBL2207364 | 0.76 | BCHE (0.43) | SLC2A1FFAR1FFAR4SIRT2PARP10 | |
| SCHEMBL4568767 | 0.76 | TLR4 (0.53) | SIRT2PARP10PARP15ADAM17TLR4 | |
| SCHEMBL4568904 | 0.76 | TLR4 (0.53) | SIRT2PARP10PARP15ADAM17TLR4 | |
| SCHEMBL4568768 | 0.76 | TLR4 (0.53) | SIRT2PARP10PARP15ADAM17TLR4 | |
| SCHEMBL2209466 | 0.75 | BCHE (0.42) | SLC2A1FFAR4SIRT2PARP10PARP15 | |
| SCHEMBL4568943 | 0.74 | — | — | |
| SCHEMBL4568813 | 0.74 | TLR4 (0.51) | PARP10PARP15TLR4TLR2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2091955-A1 | ALKOXY COMPOUNDS FOR DISEASE TREATMENT | Acucela, Inc. (US) | 2009-08-26 | — | — | EP | disclosed |
| WO-2009045479-A1 | ALKOXY COMPOUNDS FOR DISEASE TREATMENT | ACUCELA INC. (US) | 2009-04-09 | — | — | WO | disclosed |