Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 7/20 | 0.63 |
| ▸ | MEN1 | O00255 | 6/20 | 0.63 |
| ▸ | MAPT | P10636 | 4/20 | 0.63 |
| ▸ | POLB | P06746 | 3/20 | 0.63 |
| ▸ | HTT | P42858 | 2/20 | 0.63 |
| ▸ | DDX3X | O00571 | 2/20 | 0.63 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.57 |
| ▸ | BLM | P54132 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.56 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.56 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.56 |
| ▸ | CA12 | O43570 | 1/20 | 0.56 |
| ▸ | CA1 | P00915 | 1/20 | 0.56 |
| ▸ | MMP2 | P08253 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27964933 | 0.87 | KMT2A (0.69) | KMT2AMEN1MAPTPOLBHTT | |
| SCHEMBL6920322 | 0.85 | CA12 (0.58) | KMT2AMEN1MAPTPOLBHTT | |
| SCHEMBL11215471 | 0.82 | SMN1; SMN2 (0.67) | KMT2AMEN1MAPTPOLBHTT | |
| SCHEMBL3207627 | 0.81 | KMT2A (0.78) | KMT2AMEN1MAPTPOLBHTT | |
| SCHEMBL11094992 | 0.80 | MAPT (0.61) | KMT2AMEN1MAPTPOLBHTT | |
| SCHEMBL27582546 | 0.79 | KMT2A (0.67) | KMT2AMEN1MAPTPOLBHTT | |
| SCHEMBL31185157 | 0.79 | SMN1; SMN2 (0.68) | KMT2AMEN1MAPTPOLBHTT | |
| SCHEMBL3978658 | 0.79 | KMT2A (0.59) | KMT2AMEN1MAPTPOLBHTT | |
| SCHEMBL27965271 | 0.79 | CNR1 (0.64) | KMT2AMEN1MAPTPOLBHTT | |
| SCHEMBL11774149 | 0.79 | KMT2A (0.75) | KMT2AMEN1MAPTPOLBHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1907385-A4 | COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2009-05-06 | — | — | EP | disclosed |
| EP-1907385-A2 | COMPOUNDS | SmithKline Beecham Corporation (US) | 2008-04-09 | — | — | EP | disclosed |
| WO-2007018941-A2 | PYRIMIDYL-THIOPHENE DERIVATIVES | SMITHKLINE BEECHAM CORPORATION (US) | 2007-02-15 | — | — | WO | disclosed |