Climbazole

Climbazole

SCHEMBL39729

CC(C)(C)C(=O)C(Oc1ccc(Cl)cc1)n1ccnc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 3/20 1.00
KMT2A Q03164 2/20 1.00
MEN1 O00255 1/20 1.00
ADORA3 P0DMS8 1/20 1.00
CHRM1 P11229 1/20 1.00
SLC6A2 P23975 1/20 1.00
SLC6A4 P31645 1/20 1.00
ADRA1A P35348 1/20 1.00
SLC6A3 Q01959 1/20 1.00
CYP19A1 P11511 4/20 0.49
CYP26A1 O43174 3/20 0.48
CYP24A1 Q07973 3/20 0.43
LMNA P02545 1/20 0.42
TBXAS1 P24557 2/20 0.40
POLB P06746 1/20 0.40
HSP90AA1 P07900 1/20 0.40
CYP1A2 P05177 1/20 0.40
CYP2D6 P10635 1/20 0.40
CYP2C9 P11712 1/20 0.40
CYP2C19 P33261 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Climbazole SCHEMBL6235296 1.00 CYP3A4 (1.00) CYP3A4KMT2AMEN1ADORA3CHRM1
Climbazole SCHEMBL4405250 1.00 CYP3A4 (1.00) CYP3A4KMT2AMEN1ADORA3CHRM1
Climbazole SCHEMBL4879119 1.00 CYP3A4 (1.00) CYP3A4KMT2AMEN1ADORA3CHRM1
Climbazole SCHEMBL23779989 0.99 CYP3A4 (0.97) CYP3A4KMT2AMEN1ADORA3CHRM1
Climbazole SCHEMBL20504618 0.99 CYP3A4 (0.97) CYP3A4KMT2AMEN1ADORA3CHRM1
SCHEMBL11102348 0.96 CYP3A4 (0.93) CYP3A4KMT2AMEN1ADORA3CHRM1
Climbazole SCHEMBL28715628 0.96 CYP3A4 (0.93) CYP3A4KMT2AMEN1ADORA3CHRM1
Hydrochloric Acid SCHEMBL11844987 0.95 CYP3A4 (0.91) CYP3A4KMT2AMEN1ADORA3CHRM1
Climbazole SCHEMBL25437989 0.94 CYP3A4 (0.89) CYP3A4KMT2AMEN1ADORA3CHRM1
Oxalic Acid SCHEMBL11849249 0.93 CYP3A4 (0.87) CYP3A4KMT2AMEN1ADORA3CHRM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 15011 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-122075375-A Liquid crystal composition and application thereof 2026-05-26 CN claimed
WO-2026106952-A1 METHODS FOR TREATING CONGENITAL DISORDERS OF GLYCOSYLATION CDG CARE (US) 2026-05-21 WO claimed
EP-4149415-B1 SHAMPOO COMPOSITION COMPRISING ALKYL GLUCOSIDE PROCTER & GAMBLE (US) 2026-05-20 EP claimed
EP-4743051-A1 3-HYDROXYPROPYLESTERS AS SOLUBILITY ENHANCERS FOR LIPOPHILIC INGREDIENTS Symrise AG (DE) 2026-05-20 EP claimed
EP-4743053-A1 ANTIMICROBIAL SYNERGIES Symrise AG (DE) 2026-05-20 EP claimed
US-12622861-B2 Stable wash composition CONOPCO, INC. (US) 2026-05-12 US claimed
EP-4734945-A1 WASH COMPOSITION WITH ANIONIC SULFATE AND SULTAINE NOT RELIANT ON PALM KERNEL OIL Unilever IP Holdings B.V. (NL) 2026-05-06 EP claimed
EP-4729046-A2 COMPOSITIONS HAVING ENHANCED DEPOSITION OF SURFACTANT SOLUBLE ANTIDANDRUFF AGENTS The Procter & Gamble Company (US) 2026-04-22 EP claimed
US-12605322-B2 Shampoo composition with non-sulfate surfactant and complexation compound forming a coacervate WELLA INT OPERATIONS SWITZERLAND SARL (CH) 2026-04-21 US claimed
EP-4337333-B1 SHAMPOO COMPOSITION PROCTER & GAMBLE (US) 2026-04-15 EP claimed
US-4867971-A ANTIDANDRUFF COLGATE-PALMOLIVE COMPANY (US) 1989-09-19 US claimed
EP-0312234-A2 Shampoo compositions THE PROCTER & GAMBLE COMPANY (US) 1989-04-19 EP claimed
US-4670336-A AZOLE AND DIHYDROXYDIPHENYLMETHANE ANCHORING AGENTS BAYER AKTIENGESELLSCHAFT (DE) 1987-06-02 US claimed
EP-0196824-A2 Hair care compositions THE PROCTER & GAMBLE COMPANY (US) 1986-10-08 EP claimed
US-4457938-A AZOLE DERIVATIVES BAYER AKTIENGESELLSCHAFT (DE) 1984-07-03 US claimed
EP-0058887-B1 ANTIFUNGAL COMPOSITIONS WITH A HIGHER RATE OF THE DRUG RELEASE AS A STICK BAYER AG (DE) 1984-04-11 EP claimed
US-4329334-A IMIDAZOYL-1-/4-CHLOROPHENOXY/-3,3-DIMETHYLBUTANONE/2-/ COLGATE-PALMOLIVE COMPANY (US) 1982-05-11 US claimed
US-4329335-A IMIDAZOYL-1-/4-CHLOROPHENOXY/-3,3-DIMETHYLBUTANONE/2-/ COLGATE-PALMOLIVE COMPANY (US) 1982-05-11 US claimed
US-4329336-A CONTAINING 1-IMIDAZOYL-1-(4-CHLOROPHENOXY)-3,3-DIMETHYLBUTAN-2-ONE COLGATE-PALMOLIVE COMPANY (US) 1982-05-11 US claimed
EP-0011191-A1 1-(4-Chlorophenoxy)-1-(1-imidazolyl)-3,3-dimethyl-2-butanol diastereoisomers, their preparation and use in medicaments BAYER AG (DE) 1980-05-28 EP claimed