Climbazole

Climbazole

SCHEMBL4879119

CC(C)(C)C(=O)C(Oc1ccc(Cl)cc1)n1ccnc1.CC(C)(C)C(=O)C(Oc1ccc(Cl)cc1)n1ccnc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 3/20 1.00
KMT2A Q03164 2/20 1.00
MEN1 O00255 1/20 1.00
ADORA3 P0DMS8 1/20 1.00
CHRM1 P11229 1/20 1.00
SLC6A2 P23975 1/20 1.00
SLC6A4 P31645 1/20 1.00
ADRA1A P35348 1/20 1.00
SLC6A3 Q01959 1/20 1.00
CYP19A1 P11511 4/20 0.49
CYP26A1 O43174 3/20 0.48
CYP24A1 Q07973 3/20 0.43
LMNA P02545 1/20 0.42
TBXAS1 P24557 2/20 0.40
POLB P06746 1/20 0.40
HSP90AA1 P07900 1/20 0.40
CYP1A2 P05177 1/20 0.40
CYP2D6 P10635 1/20 0.40
CYP2C9 P11712 1/20 0.40
CYP2C19 P33261 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Climbazole SCHEMBL6235296 1.00 CYP3A4 (1.00) CYP3A4KMT2AMEN1ADORA3CHRM1
Climbazole SCHEMBL4405250 1.00 CYP3A4 (1.00) CYP3A4KMT2AMEN1ADORA3CHRM1
Climbazole SCHEMBL39729 1.00 CYP3A4 (1.00) CYP3A4KMT2AMEN1ADORA3CHRM1
Climbazole SCHEMBL23779989 0.99 CYP3A4 (0.97) CYP3A4KMT2AMEN1ADORA3CHRM1
Climbazole SCHEMBL20504618 0.99 CYP3A4 (0.97) CYP3A4KMT2AMEN1ADORA3CHRM1
SCHEMBL11102348 0.96 CYP3A4 (0.93) CYP3A4KMT2AMEN1ADORA3CHRM1
Climbazole SCHEMBL28715628 0.96 CYP3A4 (0.93) CYP3A4KMT2AMEN1ADORA3CHRM1
Hydrochloric Acid SCHEMBL11844987 0.95 CYP3A4 (0.91) CYP3A4KMT2AMEN1ADORA3CHRM1
Climbazole SCHEMBL25437989 0.94 CYP3A4 (0.89) CYP3A4KMT2AMEN1ADORA3CHRM1
Oxalic Acid SCHEMBL11849249 0.93 CYP3A4 (0.87) CYP3A4KMT2AMEN1ADORA3CHRM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108883038-A Composition for quick drying hair 宝洁公司 2018-11-23 CN disclosed
WO-2016030666-A1 HAIR TREATMENT COMPOSITIONS COMPRISING TERNARY SYSTEMS OF QUATERNIZED HYDROXYETHYLCELLULOSE, AMINE FUNCTIONALIZED SILICONE COMPOUNDS AND CATIONIC GUAR RECKITT BENCKISER LLC (US) 2016-03-03 WO disclosed
US-20080233057-A1 Anionic, nonionic, and/or amphoteric surfactants and mixtures; dye(s), and (micro)encapuslated dyes having a total color different from the other dyes; coacervation, precipitation; liquid soaps, hand-washing pastes, toothpastes, manual dishwashing preparations, and light-duty detergents COGNIS IP MANAGEMENT GMBH (DE) 2008-09-25 US disclosed
US-4867971-A ANTIDANDRUFF COLGATE-PALMOLIVE COMPANY (US) 1989-09-19 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080233057-A1 Anionic, nonionic, and/or amphoteric surfactants and mixtures; dye(s), and (micro)encapuslated dyes having a total color different from the other dyes; coacervation, precipitation; liquid soaps, hand-washing pastes, toothpastes, manual dishwashing preparations, and light-duty detergents S100P, PHOSPHO1, RAB5IF CYP3A4 4320/4885KMT2A 3199/4885MEN1 1268/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.