Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | PPARA | Q07869 | 14/20 | 0.44 |
| ▸ | PPARG | P37231 | 13/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | PPARD | Q03181 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.40 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3971095 | 1.00 | ALDH1A1 (0.47) | ALDH1A1MEN1KMT2APPARAPPARG | |
| SCHEMBL14281457 | 1.00 | ALDH1A1 (0.47) | ALDH1A1MEN1KMT2APPARAPPARG | |
| SCHEMBL5178764 | 0.96 | ALDH1A1 (0.44) | ALDH1A1MEN1KMT2APPARAPPARG | |
| SCHEMBL1928298 | 0.92 | PPARA (0.40) | ALDH1A1MEN1KMT2APPARAPPARG | |
| SCHEMBL14281461 | 0.90 | PPARA (0.47) | PPARAPPARGPPARDKDM4E | |
| SCHEMBL4930018 | 0.90 | PPARA (0.47) | PPARAPPARGPPARDKDM4E | |
| SCHEMBL4930024 | 0.90 | PPARA (0.47) | PPARAPPARGPPARDKDM4E | |
| SCHEMBL14281464 | 0.89 | PPARA (0.42) | ALDH1A1KMT2APPARAPPARGPPARD | |
| SCHEMBL4925236 | 0.89 | PPARA (0.42) | ALDH1A1KMT2APPARAPPARGPPARD | |
| SCHEMBL3974627 | 0.88 | ALDH1A1 (0.47) | ALDH1A1KMT2APPARAPPARGMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1778655-B1 | 2 - { - 3 2 - (PHENYL)-OXAZOL-4-YLMETHOXYL-CYCLOHEXYLMETHOXY}-PROPIONIC ACID DERIVATIVES USED AS PPAR LIGANDS (PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS) FOR THE TREATMENT OF HYPERLIPIDAEMIE AND DIABETES | SANOFI AVENTIS DEUTSCHLAND (DE) | 2009-05-06 | — | — | EP | claimed |
| US-7259177-B2 | Cycloalkylmethoxy-substituted acetic acid derivatives, processes for their preparation and their use as pharmaceuticals | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2007-08-21 | — | — | US | disclosed |