Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR3 | P49019 | 5/20 | 0.56 |
| ▸ | CISD1 | Q9NZ45 | 6/20 | 0.50 |
| ▸ | PLK1 | P53350 | 4/20 | 0.50 |
| ▸ | XDH | P47989 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3141041 | 0.99 | HCAR3 (0.57) | HCAR3CISD1PLK1XDHTSHR | |
| SCHEMBL2427920 | 0.94 | HCAR3 (0.56) | HCAR3CISD1PLK1TSHR | |
| SCHEMBL22097725 | 0.90 | HCAR3 (0.60) | HCAR3CISD1PLK1XDH | |
| SCHEMBL2425639 | 0.89 | HCAR3 (0.55) | HCAR3CISD1 | |
| SCHEMBL3975310 | 0.87 | HCAR3 (0.46) | HCAR3CISD1PLK1TSHR | |
| SCHEMBL3980340 | 0.85 | PTGER4 (0.56) | HCAR3PLK1 | |
| SCHEMBL22097708 | 0.84 | HCAR3 (0.60) | HCAR3CISD1PLK1TSHR | |
| SCHEMBL27972972 | 0.83 | KDM6B (0.55) | HCAR3CISD1PLK1TSHR | |
| SCHEMBL2432061 | 0.83 | MAPT (0.62) | HCAR3 | |
| SCHEMBL18272540 | 0.83 | PTGER4 (0.56) | HCAR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074120-A1 | TROPANE COMPOUNDS | Exelixis, Inc. (US) | 2009-07-01 | — | — | EP | disclosed |
| WO-2009055077-A1 | TROPANE COMPOUNDS | EXELIXIS, INC. (US) | 2009-04-30 | — | — | WO | disclosed |