Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 9/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 8/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 8/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | TACR1 | P25103 | 4/20 | 0.35 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
| ▸ | SSTR5 | P35346 | 5/20 | 0.35 |
| ▸ | HRH1 | P35367 | 2/20 | 0.35 |
| ▸ | SSTR1 | P30872 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3927956 | 0.81 | SLC6A4 (0.39) | SLC6A4SLC6A2SLC6A3KCNH2TACR1 | |
| SCHEMBL3925317 | 0.80 | SLC6A4 (0.38) | SLC6A4SLC6A2SLC6A3KCNH2TACR1 | |
| SCHEMBL3930491 | 0.79 | TACR1 (0.39) | SLC6A4SLC6A2SLC6A3KCNH2TACR1 | |
| SCHEMBL4222744 | 0.79 | TACR1 (0.38) | SLC6A4SLC6A2SLC6A3KCNH2TACR1 | |
| SCHEMBL3978586 | 0.79 | PROKR1 (0.41) | SLC6A4SLC6A2SLC6A3KCNH2TACR1 | |
| SCHEMBL3973812 | 0.79 | SSTR5 (0.38) | SLC6A4SLC6A2SLC6A3KCNH2TACR1 | |
| SCHEMBL4702470 | 0.79 | SLC6A4 (0.48) | SLC6A4SLC6A2SLC6A3KCNH2TACR1 | |
| SCHEMBL3977983 | 0.78 | SSTR5 (0.41) | SLC6A4SLC6A2SLC6A3KCNH2TACR1 | |
| SCHEMBL3971319 | 0.78 | REN (0.42) | SLC6A4SLC6A2SLC6A3KCNH2TACR1 | |
| SCHEMBL3976469 | 0.77 | SLC6A2 (0.40) | SLC6A4SLC6A2SLC6A3HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2054385-A2 | PHENYL, PYRIDINE AND QUINOLINE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2009-05-06 | — | — | EP | claimed |
| WO-2008019967-A2 | PHENYL, PYRIDINE AND QUINOLINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-02-21 | — | — | WO | claimed |
| EP-2054385-A2 | PHENYL, PYRIDINE AND QUINOLINE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2009-05-06 | — | — | EP | disclosed |
| WO-2008019967-A2 | PHENYL, PYRIDINE AND QUINOLINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-02-21 | — | — | WO | disclosed |