SCHEMBL3973897

SCHEMBL3973897

COc1ccc(Nc2ccc(CCNCC(O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1-c1ccccc1.O=c1ccc2c(C(O)CNCCCCCCNCCc3ccccc3)ccc(O)c2[nH]1

nearest known ligand 0.92

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
ADRB2 P07550 20/20 0.92
ADRB1 P08588 15/20 0.92
ADRB3 P13945 7/20 0.92
DRD2 P14416 2/20 0.68
DRD1 P21728 2/20 0.68
DRD4 P21917 2/20 0.68
DRD3 P35462 2/20 0.68

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29390087 0.96 ADRB2 (1.00) ADRB2ADRB1ADRB3DRD2DRD1
SCHEMBL29798936 0.96 ADRB2 (1.00) ADRB2ADRB1ADRB3DRD2DRD1
SCHEMBL246986 0.96 ADRB2 (1.00) ADRB2ADRB1ADRB3DRD2DRD1
SCHEMBL335742 0.96 ADRB2 (1.00) ADRB2ADRB1ADRB3DRD2DRD1
Hydrochloric Acid SCHEMBL4385888 0.95 ADRB2 (0.98) ADRB2ADRB1ADRB3DRD2DRD1
Hydrochloric Acid SCHEMBL4393368 0.94 ADRB2 (0.97) ADRB2ADRB1ADRB3DRD2DRD1
SCHEMBL3837610 0.90 ADRB2 (0.86) ADRB2ADRB1ADRB3DRD2DRD1
SCHEMBL3842080 0.90 ADRB2 (0.89) ADRB2ADRB1ADRB3DRD2DRD1
SCHEMBL3837623 0.89 ADRB2 (0.85) ADRB2ADRB1ADRB3DRD2DRD1
SCHEMBL3844725 0.89 ADRB2 (0.87) ADRB2ADRB1ADRB3DRD2DRD1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2009095160-A1 NOZZLE AND INHALER AND METHOD FOR PRODUCING A NOZZLE BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) 2009-08-06 WO disclosed
EP-2079731-A1 NOVEL SUBSTITUTED PIPERIDYL-PROPANE-THIOLS Boehringer Ingelheim International GmbH (DE) 2009-07-22 EP disclosed
EP-2015811-A1 ATOMIZER AND METHOD OF ATOMIZING FLUID Boehringer Ingelheim International GmbH (DE) 2009-01-21 EP disclosed
WO-2008049875-A1 NOVEL SUBSTITUTED PIPERIDYL-PROPANE-THIOLS BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2008-05-02 WO disclosed
WO-2007128381-A1 ATOMIZER AND METHOD OF ATOMIZING FLUID BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2007-11-15 WO disclosed