Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | TSHR | P16473 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | TP53 | P04637 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | CRHBP | P24387 | 1/20 | 0.39 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3172001 | 1.00 | SMN1; SMN2 (0.42) | SMN1; SMN2ALDH1A1TSHRLMNAHTT | |
| SCHEMBL3181831 | 0.89 | SMN1; SMN2 (0.42) | SMN1; SMN2ALDH1A1TSHRLMNAHTT | |
| SCHEMBL3968856 | 0.89 | LMNA (0.45) | SMN1; SMN2ALDH1A1TSHRLMNAHTT | |
| SCHEMBL3181486 | 0.89 | LMNA (0.45) | SMN1; SMN2ALDH1A1TSHRLMNAHTT | |
| SCHEMBL3181418 | 0.86 | PDE2A (0.39) | SMN1; SMN2ALDH1A1TSHRLMNAHTT | |
| SCHEMBL3186439 | 0.86 | PDE2A (0.39) | SMN1; SMN2ALDH1A1TSHRLMNAHTT | |
| SCHEMBL3666251 | 0.86 | PDE2A (0.39) | SMN1; SMN2ALDH1A1TSHRLMNAHTT | |
| SCHEMBL3171841 | 0.84 | LMNA (0.42) | TSHRLMNAHTTRAB9ANPC1 | |
| SCHEMBL3664032 | 0.84 | LMNA (0.42) | TSHRLMNAHTTRAB9ANPC1 | |
| SCHEMBL3173484 | 0.84 | LMNA (0.42) | TSHRLMNAHTTRAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2051977-A2 | SUBSTITUTED AZOLE AROMATIC HETEROCYCLES AS INHIBITORS OF LLbeta-HSD-1 | Amgen Inc. (US) | 2009-04-29 | — | — | EP | disclosed |
| WO-2008011453-A2 | SUBSTITUTED AZOLE AROMATIC HETEROCYCLES AS INHIBITORS OF LLβ-HSD-1 | AMGEN INC. (US) | 2008-01-24 | — | — | WO | disclosed |