Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 1/20 | 0.71 |
| ▸ | CA2 | P00918 | 1/20 | 0.71 |
| ▸ | CA9 | Q16790 | 1/20 | 0.71 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | FFAR3 | O14843 | 2/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | FYN | P06241 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 5/20 | 0.33 |
| ▸ | LDHA | P00338 | 2/20 | 0.33 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.33 |
| ▸ | LDHB | P07195 | 1/20 | 0.33 |
| ▸ | SRR | Q9GZT4 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.33 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.33 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.33 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.31 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.31 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL177966 | 1.00 | CA1 (0.71) | CA1CA2CA9LMNAFFAR3 | |
| Bicarbonate SCHEMBL6065486 | 1.00 | CA1 (0.71) | CA1CA2CA9LMNAFFAR3 | |
| Bicarbonate SCHEMBL4649251 | 1.00 | CA1 (0.71) | CA1CA2CA9LMNAFFAR3 | |
| Bicarbonate SCHEMBL20650 | 1.00 | — | — | |
| Bicarbonate SCHEMBL10831385 | 1.00 | CA1 (0.71) | CA1CA2CA9LMNAFFAR3 | |
| Bicarbonate SCHEMBL1022672 | 1.00 | CA1 (0.71) | CA1CA2CA9LMNAFFAR3 | |
| Bicarbonate SCHEMBL166967 | 1.00 | — | — | |
| Bicarbonate SCHEMBL968687 | 1.00 | CA1 (0.71) | CA1CA2CA9LMNAFFAR3 | |
| Bicarbonate SCHEMBL23802372 | 0.94 | — | — | |
| Bicarbonate SCHEMBL1801942 | 0.94 | CA1 (0.62) | CA1CA2CA9LMNAFFAR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 57 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112745050-B | Preparation method of modified limestone powder for mass concrete | 中建商品混凝土有限公司 | 2022-03-18 | — | — | CN | claimed |
| CN-112745050-A | Preparation method of modified limestone powder for mass concrete | 中建商品混凝土有限公司 | 2021-05-04 | — | — | CN | claimed |
| US-20040091772-A1 | Lithium-ion battery electrolytes with improved thermal stability | YARDNEY TECHNICAL PRODUCTS, INC. | 2004-05-13 | — | — | US | claimed |
| CN-114605289-A | Carbamate compound for non-aqueous electrolyte and application thereof | 湖州师范学院 | 2022-06-10 | — | — | CN | disclosed |
| CN-112745050-B | Preparation method of modified limestone powder for mass concrete | 中建商品混凝土有限公司 | 2022-03-18 | — | — | CN | disclosed |
| CN-113195699-A | Detergent composition and washing method using same | 凯斯科技股份有限公司 | 2021-07-30 | — | — | CN | disclosed |
| CN-112745050-A | Preparation method of modified limestone powder for mass concrete | 中建商品混凝土有限公司 | 2021-05-04 | — | — | CN | disclosed |
| EP-3684836-A1 | PROCESS FOR PRODUCING A LACTONE COPOLYMER | Ingevity UK Ltd (GB) | 2020-07-29 | — | — | EP | disclosed |
| US-20200216608-A1 | PROCESS FOR PRODUCING A LACTONE COPOLYMER | INGEVITY UK LTD (GB) | 2020-07-09 | — | — | US | disclosed |
| US-10314885-B2 | Oxytocin treatment to modify blood glucose and treat metabolic disease | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2019-06-11 | — | — | US | disclosed |
| WO-2019059834-A1 | PROCESS FOR PRODUCING A LACTONE COPOLYMER | PERSTORP AB (SE) | 2019-03-28 | — | — | WO | disclosed |
| US-20030118630-A1 | Immune modulation device for use in animals | APPLIED VACCINE TECHNOLOGIES CORP. | 2003-06-26 | — | — | US | disclosed |
| US-20030109419-A1 | Method for classification of anti-psychotic drugs | ROCKEFELLER UNIVERSITY, THE | 2003-06-12 | — | — | US | disclosed |
| WO-2003020161-A2 | IMMUNE MODULATION DEVICE FOR USE IN ANIMALS | APPLIED VACCINE TECHNOLOGIES CORP. (US) | 2003-03-13 | — | — | WO | disclosed |
| WO-2003021225-A2 | METHOD FOR CLASSIFICATION OF ANTI-PSYCHOTIC DRUGS | THE ROCKEFELLER UNIVERSITY (US) | 2003-03-13 | — | — | WO | disclosed |
| WO-2003020702-A2 | PHOSPHODIESTERASE ACTIVITY AND REGULATION OF PHOSPHODIESTERASE 1-B-MEDIATED SIGNALING IN BRAIN | THE ROCKEFELLER UNIVERSITY (US) | 2003-03-13 | — | — | WO | disclosed |
| WO-2003014321-A2 | COMPOSITIONS AND METHODS FOR MODULATION OF DARPP-32 PHOSPHORYLATION | THE ROCKEFELLER UNIVERSITY (US) | 2003-02-20 | — | — | WO | disclosed |
| WO-2002102768-A2 | REGULATION OF NEURONAL FUNCTION THROUGH METABOTROPIC GLUTAMATE RECEPTOR SIGNALING PATHWAYS | THE ROCKEFELLER UNIVERSITY (US) | 2002-12-27 | — | — | WO | disclosed |
| US-20010017138-A1 | Medical device for treatment of a gap or defect in the central nerve system | KAROLINSKA INNOVATIONS AB (SE) | 2001-08-30 | — | — | US | disclosed |
| US-4689353-A | Hydroxy and amino-functional polyahls containing carbonate, urethane and/or urea moieties | THE DOW CHEMICAL COMPANY (US) | 1987-08-25 | — | — | US | disclosed |