Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SHBG | P04278 | 1/20 | 0.57 |
| ▸ | STS | P08842 | 11/20 | 0.43 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | ESR1 | P03372 | 2/20 | 0.39 |
| ▸ | PGR | P06401 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | AR | P10275 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3974913 | 0.81 | SHBG (0.60) | SHBGSTSHSD17B1LMNAMAPT | |
| SCHEMBL7163758 | 0.81 | SHBG (0.66) | SHBGSTSHSD17B1LMNAMAPT | |
| SCHEMBL10439848 | 0.80 | SHBG (0.65) | SHBGSTSHSD17B1LMNAMAPT | |
| SCHEMBL8571107 | 0.75 | SHBG (0.60) | SHBGSTSHSD17B1LMNAMAPT | |
| SCHEMBL7864592 | 0.73 | SHBG (1.00) | SHBGSTSHSD17B1LMNAMAPT | |
| SCHEMBL712443 | 0.73 | SHBG (1.00) | SHBGSTSHSD17B1LMNAMAPT | |
| SCHEMBL29643366 | 0.73 | SHBG (1.00) | SHBGSTSHSD17B1LMNAMAPT | |
| SCHEMBL172746 | 0.73 | SHBG (1.00) | SHBGSTSHSD17B1LMNAMAPT | |
| SCHEMBL27553583 | 0.73 | ESR1 (0.67) | SHBGSTSLMNAMAPTKMT2A | |
| SCHEMBL9367031 | 0.73 | SHBG (0.45) | SHBGSTSHSD17B1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1773349-A4 | METHODS AND COMPOSITIONS FOR TREATMENT OF PREECLAMPSIA | CHILDRENS MEDICAL CENTER (US) | 2009-07-29 | — | — | EP | disclosed |
| EP-1773349-A2 | METHODS AND COMPOSITIONS FOR TREATMENT OF PREECLAMPSIA | CHILDREN'S MEDICAL CENTER CORPORATION (US) | 2007-04-18 | — | — | EP | disclosed |
| WO-2005110462-A2 | METHODS AND COMPOSITIONS FOR TREATMENT OF PREECLAMPSIA | CHILDREN'S MEDICAL CENTER CORPORATION (US) | 2005-11-24 | — | — | WO | disclosed |