Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 2/20 | 0.43 |
| ▸ | JAK3 | P52333 | 2/20 | 0.43 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.43 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.42 |
| ▸ | SRC | P12931 | 12/20 | 0.42 |
| ▸ | KDR | P35968 | 4/20 | 0.42 |
| ▸ | YES1 | P07947 | 3/20 | 0.42 |
| ▸ | EPHB4 | P54760 | 3/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.42 |
| ▸ | ABL1 | P00519 | 2/20 | 0.42 |
| ▸ | LCK | P06239 | 2/20 | 0.42 |
| ▸ | LYN | P07948 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | RAF1 | P04049 | 1/20 | 0.42 |
| ▸ | FYN | P06241 | 1/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.42 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13883511 | 0.89 | SRC (0.52) | JAK2JAK3PTK2PDPK1SRC | |
| SCHEMBL13881584 | 0.85 | AXL (0.56) | JAK2JAK3PTK2SRCKDR | |
| SCHEMBL13883580 | 0.84 | AXL (0.46) | JAK2JAK3SRCKDRYES1 | |
| SCHEMBL3964683 | 0.82 | AXL (0.48) | JAK2JAK3PTK2SRCKDR | |
| SCHEMBL13883618 | 0.81 | JAK2 (0.43) | JAK2JAK3PTK2AXLRET | |
| SCHEMBL13883570 | 0.80 | BACE1 (0.41) | JAK2JAK3PTK2AXLRET | |
| SCHEMBL3966481 | 0.80 | BACE1 (0.48) | JAK2JAK3PTK2SRCKDR | |
| SCHEMBL3969268 | 0.79 | HRH3 (0.46) | JAK2JAK3PTK2PDPK1SRC | |
| SCHEMBL13883471 | 0.79 | SRC (0.52) | JAK2JAK3SRCKDRYES1 | |
| SCHEMBL13883571 | 0.79 | SRC (0.46) | JAK2JAK3SRCKDRYES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009049028-A1 | PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USE AS JANUS KINASE MODULATORS | TARGEGEN INC. (US) | 2009-04-16 | — | — | WO | disclosed |
| WO-2009049028-A1 | PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USE AS JANUS KINASE MODULATORS | TARGEGEN INC. (US) | 2009-04-16 | — | — | WO | disclosed |