Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 5/20 | 0.48 |
| ▸ | AXL | P30530 | 4/20 | 0.46 |
| ▸ | INSR | P06213 | 2/20 | 0.46 |
| ▸ | IKBKB | O14920 | 1/20 | 0.44 |
| ▸ | CHUK | O15111 | 1/20 | 0.44 |
| ▸ | IKBKG | Q9Y6K9 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 2/20 | 0.43 |
| ▸ | JAK3 | P52333 | 2/20 | 0.43 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | SRC | P12931 | 2/20 | 0.43 |
| ▸ | YES1 | P07947 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.43 |
| ▸ | LTA4H | P09960 | 4/20 | 0.43 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13883619 | 0.89 | AXL (0.43) | BACE1AXLINSRSRCYES1 | |
| SCHEMBL13883460 | 0.88 | BACE1 (0.40) | BACE1AXLINSRJAK2JAK3 | |
| SCHEMBL3969296 | 0.88 | BACE1 (0.40) | BACE1AXLINSRJAK2JAK3 | |
| SCHEMBL3975437 | 0.84 | CDK1 (0.42) | IKBKBCHUKIKBKGHRH3KDR | |
| SCHEMBL13883580 | 0.84 | AXL (0.46) | BACE1AXLINSRJAK2JAK3 | |
| SCHEMBL3969268 | 0.84 | HRH3 (0.46) | BACE1AXLJAK2JAK3PTK2 | |
| SCHEMBL13883585 | 0.84 | AXL (0.40) | BACE1AXLSRCYES1KDR | |
| SCHEMBL3964683 | 0.83 | AXL (0.48) | BACE1AXLINSRJAK2JAK3 | |
| SCHEMBL13883618 | 0.83 | JAK2 (0.43) | BACE1AXLINSRJAK2JAK3 | |
| SCHEMBL13883716 | 0.83 | AXL (0.45) | AXLJAK2JAK3SRCYES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009049028-A1 | PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USE AS JANUS KINASE MODULATORS | TARGEGEN INC. (US) | 2009-04-16 | — | — | WO | claimed |
| WO-2009049028-A1 | PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USE AS JANUS KINASE MODULATORS | TARGEGEN INC. (US) | 2009-04-16 | — | — | WO | disclosed |
| WO-2009049028-A1 | PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USE AS JANUS KINASE MODULATORS | TARGEGEN INC. (US) | 2009-04-16 | — | — | WO | disclosed |