Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX4 | Q99571 | 13/20 | 0.48 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | P2RX1 | P51575 | 2/20 | 0.38 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.38 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.38 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.38 |
| ▸ | ITGAL | P20701 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19175897 | 0.74 | P2RX4 (0.48) | P2RX4ALOX5MAOAMAOBP2RX1 | |
| SCHEMBL31067286 | 0.74 | KDM4E (0.55) | P2RX4MAOAP2RX1MAPTSMN1; SMN2 | |
| SCHEMBL10586348 | 0.74 | P2RX4 (0.48) | P2RX4ALOX5MAOAMAOBP2RX1 | |
| SCHEMBL949678 | 0.74 | P2RX4 (0.54) | P2RX4ALOX5MAOAMAOBP2RX1 | |
| SCHEMBL31191643 | 0.74 | P2RX4 (0.48) | P2RX4ALOX5MAOAMAOBP2RX1 | |
| SCHEMBL20308266 | 0.74 | P2RX4 (0.48) | P2RX4ALOX5MAOAMAOBP2RX1 | |
| SCHEMBL13150242 | 0.74 | P2RX4 (0.48) | P2RX4ALOX5MAOAMAOBP2RX1 | |
| SCHEMBL47007 | 0.74 | KDM4E (0.55) | P2RX4MAOAP2RX1MAPTSMN1; SMN2 | |
| SCHEMBL18579885 | 0.73 | P2RX4 (0.44) | P2RX4P2RX1P2RX3MAPTSMN1; SMN2 | |
| SCHEMBL3969789 | 0.73 | P2RX4 (0.44) | P2RX4ALOX5P2RX1P2RX3MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7595317-B2 | Barbituric acid derivatives as inhibitors of TNF-α converting enzyme (TACE) and/or matrix metalloproteinases | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-09-29 | — | — | US | disclosed |
| US-7294624-B2 | Osteoporosis; antiarthritic agents | BRISTOL MYERS SQUIBB COMPANY (US) | 2007-11-13 | — | — | US | disclosed |