Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 13/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.54 |
| ▸ | HTR1A | P08908 | 8/20 | 0.52 |
| ▸ | HTR2A | P28223 | 8/20 | 0.52 |
| ▸ | DRD2 | P14416 | 8/20 | 0.52 |
| ▸ | HTR2C | P28335 | 6/20 | 0.52 |
| ▸ | DRD4 | P21917 | 6/20 | 0.51 |
| ▸ | HRH1 | P35367 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8223703 | 0.94 | DRD3 (0.54) | DRD3KCNH2HTR1AHTR2ADRD2 | |
| SCHEMBL3977165 | 0.89 | DRD3 (0.55) | DRD3KCNH2HTR1AHTR2ADRD2 | |
| SCHEMBL13484840 | 0.88 | DRD3 (0.62) | DRD3KCNH2HTR1AHTR2ADRD2 | |
| SCHEMBL13484913 | 0.88 | DRD3 (0.55) | DRD3HTR1AHTR2ADRD2HTR2C | |
| SCHEMBL3976216 | 0.88 | DRD3 (0.55) | DRD3KCNH2HTR1AHTR2ADRD2 | |
| SCHEMBL8231863 | 0.86 | DRD3 (0.60) | DRD3KCNH2HTR1AHTR2ADRD2 | |
| SCHEMBL8223541 | 0.86 | DRD3 (0.62) | DRD3KCNH2HTR1AHTR2ADRD2 | |
| SCHEMBL13484897 | 0.85 | DRD3 (0.57) | DRD3KCNH2HTR1AHTR2ADRD2 | |
| SCHEMBL3978987 | 0.85 | DRD4 (0.52) | DRD3HTR1AHTR2ADRD2HTR2C | |
| SCHEMBL13484907 | 0.84 | DRD3 (0.49) | DRD3HTR1AHTR2ADRD2HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2057138-A1 | NOVEL CHROMENE AND THIOCHROMENE CARBOXAMIDE DERIVATIVES, METHODS FOR PREPARING SAME AND THERAPEUTIC APPLICATIONS OF SAME | Pierre Fabre Medicament (FR) | 2009-05-13 | — | — | EP | claimed |
| WO-2008009741-A1 | NOVEL CHROMENE AND THIOCHROMENE CARBOXAMIDE DERIVATIVES, METHODS FOR PREPARING SAME AND THERAPEUTIC APPLICATIONS OF SAME | PIERRE FABRE MEDICAMENT (FR) | 2008-01-24 | — | — | WO | claimed |
| US-20100029682-A1 | NOVEL CHROMENE AND THIOCHROMENE CARBOXAMIDE DERIVATIVES, METHODS FOR PREPARING SAME AND THERAPEUTIC APPLICATIONS OF SAME | PIERRE FABRE MEDICAMENT (FR) | 2010-02-04 | — | — | US | disclosed |
| US-20100029682-A1 | NOVEL CHROMENE AND THIOCHROMENE CARBOXAMIDE DERIVATIVES, METHODS FOR PREPARING SAME AND THERAPEUTIC APPLICATIONS OF SAME | PIERRE FABRE MEDICAMENT (FR) | 2010-02-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100029682-A1 | NOVEL CHROMENE AND THIOCHROMENE CARBOXAMIDE DERIVATIVES, METHODS FOR PREPARING SAME AND THERAPEUTIC APPLICATIONS OF SAME | DRD3, CHRNA3, CHRM3 | DRD3 1/4885KCNH2 1015/4885HTR1A 66/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.