Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCAT2 | O15382 | 2/20 | 0.44 |
| ▸ | ALOX5AP | P20292 | 3/20 | 0.37 |
| ▸ | FEN1 | P39748 | 3/20 | 0.37 |
| ▸ | IKBKB | O14920 | 3/20 | 0.36 |
| ▸ | PLA2G2A | P14555 | 3/20 | 0.36 |
| ▸ | PLA2G10 | O15496 | 2/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.34 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.34 |
| ▸ | CHUK | O15111 | 1/20 | 0.34 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.34 |
| ▸ | PKMYT1 | Q99640 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3981622 | 0.86 | BCAT2 (0.44) | BCAT2ALOX5APFEN1IKBKBPLA2G2A | |
| SCHEMBL3974955 | 0.85 | BCAT2 (0.43) | BCAT2IKBKBPLA2G2APLA2G10BRD4 | |
| SCHEMBL3975515 | 0.83 | BCAT2 (0.54) | BCAT2IKBKBPLA2G2APLA2G10KDM4E | |
| SCHEMBL23573105 | 0.76 | BCAT2 (0.58) | BCAT2ALOX5APFEN1IKBKBPLA2G2A | |
| SCHEMBL3979295 | 0.72 | BCAT2 (0.43) | BCAT2IKBKBPLA2G2APLA2G10BRD4 | |
| SCHEMBL3974889 | 0.71 | MKNK1 (0.47) | KDM4EPARP10HTTSMN1; SMN2 | |
| SCHEMBL30841448 | 0.70 | BCAT2 (0.69) | BCAT2IKBKBKDM4EPDK2HTT | |
| SCHEMBL3973836 | 0.69 | BCAT2 (0.54) | BCAT2IKBKBKDM4EHTTSMN1; SMN2 | |
| SCHEMBL18816701 | 0.69 | BCAT2 (0.53) | BCAT2IKBKBBRD4KDM4EPARP10 | |
| SCHEMBL27674225 | 0.69 | BCAT2 (0.49) | BCAT2IKBKBPLA2G2APLA2G10BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2054383-A2 | NOVEL COMPOUNDS AS ANTAGONISTS OR INVERSE AGONISTS AT OPIOID RECEPTORS | SmithKline Beecham Corporation (US) | 2009-05-06 | — | — | EP | disclosed |
| WO-2008021849-A2 | NOVEL COMPOUNDS AS ANTAGONISTS OR INVERSE AGONISTS AT OPIOID RECEPTORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-02-21 | — | — | WO | disclosed |