SCHEMBL3975751

SCHEMBL3975751

CCc1ccc(Nc2ccc(Nc3ccc(CC)cc3)c3c2C(=O)c2ccccc2C3=O)cc1

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ P2RY4 P51582 5/20 0.62
▸ NPC1 O15118 4/20 0.60
▸ RAB9A P51151 4/20 0.60
▸ LMNA P02545 3/20 0.60
▸ MAPK1 P28482 3/20 0.60
▸ TDP1 Q9NUW8 2/20 0.60
▸ MAPT P10636 2/20 0.60
▸ L3MBTL1 Q9Y468 2/20 0.60
▸ MEN1 O00255 2/20 0.60
▸ KMT2A Q03164 2/20 0.60
▸ NPSR1 Q6W5P4 1/20 0.60
▸ APAF1 O14727 2/20 0.60
▸ MITF O75030 1/20 0.60
▸ ALDH1A1 P00352 1/20 0.49
▸ SMN1; SMN2 Q16637 1/20 0.49
▸ RPS6KA2 Q15349 1/20 0.48
▸ PRKCA P17252 1/20 0.47
▸ P2RY12 Q9H244 1/20 0.46
▸ CYP1A2 P05177 2/20 0.46
▸ TSHR P16473 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13893952 0.94 P2RY4 (0.57) P2RY4NPC1RAB9ALMNAMAPK1
SCHEMBL13893905 0.92 MEN1 (0.74) P2RY4NPC1RAB9ALMNAMAPK1
SCHEMBL11540883 0.92 P2RY4 (0.61) P2RY4NPC1RAB9ALMNAMAPK1
SCHEMBL13962358 0.88 P2RY4 (0.48) P2RY4NPC1RAB9ALMNAMAPK1
SCHEMBL13884828 0.88 MEN1 (0.70) P2RY4NPC1RAB9ALMNAMAPK1
SCHEMBL13135365 0.88 NPC1 (0.65) P2RY4NPC1RAB9ALMNAMAPK1
SCHEMBL375206 0.87 TDP1 (0.52) P2RY4NPC1RAB9ALMNAMAPK1
SCHEMBL10732288 0.85 NPC1 (0.62) P2RY4NPC1RAB9ALMNAMAPK1
SCHEMBL375375 0.84 P2RY4 (0.50) P2RY4NPC1RAB9ALMNAMAPK1
SCHEMBL14489853 0.83 NPC1 (0.60) P2RY4NPC1RAB9ALMNAMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10765508-B2 Ocular mask having selective spectral transmission AcFocus, Inc. (US) 2020-09-08 — — US disclosed
US-20190314146-A1 OCULAR MASK HAVING SELECTIVE SPECTRAL TRANSMISSION ACUFOCUS, INC. 2019-10-17 — — US disclosed
US-10342656-B2 Ocular mask having selective spectral transmission ACUFOCUS, INC. (US) 2019-07-09 — — US disclosed
EP-2785296-B1 OCULAR MASK HAVING SELECTIVE SPECTRAL TRANSMISSION ACUFOCUS INC (US) 2018-06-20 — — EP disclosed
US-20180125639-A1 OCULAR MASK HAVING SELECTIVE SPECTRAL TRANSMISSION ACUFOCUS, INC. 2018-05-10 — — US disclosed
US-9848979-B2 Ocular mask having selective spectral transmission ACUFOCUS, INC. (US) 2017-12-26 — — US disclosed
US-20170189167-A1 OCULAR MASK HAVING SELECTIVE SPECTRAL TRANSMISSION ACUFOCUS, INC. 2017-07-06 — — US disclosed
US-9545303-B2 Ocular mask having selective spectral transmission ACUFOCUS, INC. (US) 2017-01-17 — — US disclosed
EP-2785296-A1 OCULAR MASK HAVING SELECTIVE SPECTRAL TRANSMISSION AcuFocus, Inc. (US) 2014-10-08 — — EP disclosed
US-20130268071-A1 OCULAR MASK HAVING SELECTIVE SPECTRAL TRANSMISSION HEALTHCARE ROYALTY PARTNERS II, L.P. 2013-10-10 — — US disclosed
WO-2013081094-A1 IMIDAZO[1,2-A]PYRIDINE DERIVATIVE AND USE THEREOF FOR MEDICAL PURPOSES 東レ株式会社 (JP) 2013-06-06 — — WO disclosed
WO-2013082545-A1 OCULAR MASK HAVING SELECTIVE SPECTRAL TRANSMISSION ACUFOCUS, INC. (US) 2013-06-06 — — WO disclosed
US-7504495-B2 Quencher compositions comprising anthraquinone moieties EXIQON A/S (DK) 2009-03-17 — — US disclosed
EP-1538154-B1 Quencher composition comprising anthraquinone moieties EXIQON AS (DK) 2008-12-31 — — EP disclosed
US-20050227254-A1 Quencher compositions comprising anthraquinone moieties QIAGEN GMBH (DE) 2005-10-13 — — US disclosed
EP-1538154-A1 Quencher composition comprising anthraquinone moieties Exiqon A/S (DK) 2005-06-08 — — EP disclosed
US-4702561-A AMINOANTHRAQUINONE BISANIL MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1987-10-27 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050227254-A1 Quencher compositions comprising anthraquinone moieties ANXA5, SUN2, ANXA3 P2RY4 358/4885NPC1 4101/4885RAB9A 3485/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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