Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 8/20 | 0.59 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.53 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.52 |
| ▸ | WNT3A | P56704 | 1/20 | 0.52 |
| ▸ | CKS1B | P61024 | 2/20 | 0.51 |
| ▸ | SKP1 | P63208 | 2/20 | 0.51 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.51 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.50 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | ADK | P55263 | 1/20 | 0.48 |
| ▸ | RET | P07949 | 3/20 | 0.47 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31662843 | 0.91 | GPR119 (0.61) | GPR119AOC3MAP4K4WNT3ACKS1B | |
| SCHEMBL3975617 | 0.89 | GPR119 (0.60) | GPR119AOC3MAP4K4WNT3ACKS1B | |
| SCHEMBL24478929 | 0.88 | GPR119 (0.59) | GPR119AOC3MAP4K4WNT3ACKS1B | |
| SCHEMBL30539162 | 0.88 | GPR119 (0.59) | GPR119AOC3MAP4K4WNT3ACKS1B | |
| SCHEMBL20120820 | 0.87 | GPR119 (0.58) | GPR119AOC3MAP4K4WNT3ACKS1B | |
| SCHEMBL31627702 | 0.87 | GPR119 (0.58) | GPR119AOC3MAP4K4WNT3ACKS1B | |
| SCHEMBL29773872 | 0.87 | GPR119 (0.58) | GPR119AOC3MAP4K4WNT3ACKS1B | |
| SCHEMBL26759314 | 0.87 | GPR119 (0.62) | GPR119MAP4K4WNT3ACKS1BSKP1 | |
| SCHEMBL20425026 | 0.85 | GPR119 (0.60) | GPR119AOC3MAP4K4WNT3ACKS1B | |
| SCHEMBL31420076 | 0.85 | GPR119 (0.60) | GPR119AOC3MAP4K4WNT3ACKS1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074120-A1 | TROPANE COMPOUNDS | Exelixis, Inc. (US) | 2009-07-01 | — | — | EP | disclosed |
| WO-2009055077-A1 | TROPANE COMPOUNDS | EXELIXIS, INC. (US) | 2009-04-30 | — | — | WO | disclosed |