Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 20/20 | 0.46 |
| ▸ | AKT2 | P31751 | 1/20 | 0.34 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3978929 | 0.90 | AKT1 (0.55) | AKT1AKT2AKT3 | |
| SCHEMBL3948631 | 0.88 | AKT1 (0.39) | AKT1AKT2AKT3 | |
| SCHEMBL3943219 | 0.84 | AKT1 (0.51) | AKT1AKT2AKT3 | |
| SCHEMBL2573577 | 0.79 | AKT1 (0.51) | AKT1AKT2AKT3 | |
| SCHEMBL3944423 | 0.77 | AKT1 (0.46) | AKT1AKT2AKT3 | |
| SCHEMBL2577390 | 0.76 | AKT1 (0.63) | AKT1 | |
| SCHEMBL2571892 | 0.74 | AKT1 (0.63) | AKT1AKT2AKT3 | |
| SCHEMBL2574577 | 0.74 | AKT1 (0.63) | AKT1AKT2AKT3 | |
| SCHEMBL2571895 | 0.74 | AKT1 (0.63) | AKT1AKT2AKT3 | |
| SCHEMBL3976015 | 0.74 | AKT1 (0.57) | AKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2054418-A1 | DIHYDROTHIENO PYRIMIDINES AS AKT PROTEIN KINASE INHIBITORS | Array Biopharma, Inc. (US) | 2009-05-06 | — | — | EP | disclosed |
| WO-2008006039-A1 | DIHYDROTHIENO PYRIMIDINES AS AKT PROTEIN KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2008-01-10 | — | — | WO | disclosed |