Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 9/20 | 0.84 |
| ▸ | KDR | P35968 | 2/20 | 0.49 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | KCNQ3 | O43525 | 2/20 | 0.48 |
| ▸ | KCNQ2 | O43526 | 2/20 | 0.48 |
| ▸ | KCNE1 | P15382 | 2/20 | 0.48 |
| ▸ | KCNQ1 | P51787 | 2/20 | 0.48 |
| ▸ | KCNQ5 | Q9NR82 | 1/20 | 0.47 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.45 |
| ▸ | TEK | Q02763 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.44 |
| ▸ | PIP4K2C | Q8TBX8 | 1/20 | 0.44 |
| ▸ | CSF1R | P07333 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3978525 | 0.91 | BRAF (1.00) | BRAFKDRPDGFRBMAPTKCNK3 | |
| SCHEMBL4205684 | 0.90 | BRAF (0.88) | BRAFKDRPDGFRBMAPTKCNQ3 | |
| SCHEMBL4195742 | 0.89 | BRAF (0.81) | BRAFKDRPDGFRBMAPTKCNK3 | |
| SCHEMBL4200345 | 0.88 | BRAF (1.00) | BRAFKDRPDGFRBMAPTTEK | |
| SCHEMBL4190532 | 0.85 | BRAF (0.79) | BRAFKDRPDGFRBMAPTKCNK3 | |
| SCHEMBL4192912 | 0.84 | BRAF (0.77) | BRAFKDRPDGFRBMAPTKCNK3 | |
| SCHEMBL3980014 | 0.82 | BRAF (0.73) | BRAFKDRPDGFRBMAPTKCNQ3 | |
| SCHEMBL3982001 | 0.82 | BRAF (0.73) | BRAFKDRPDGFRBMAPTKCNQ3 | |
| SCHEMBL4195978 | 0.82 | BRAF (0.76) | BRAFKDRKCNQ3KCNQ2KCNE1 | |
| SCHEMBL4199752 | 0.82 | BRAF (0.82) | BRAFKDRMAPTTEK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090118276-A1 | THIENOPYRIMIDINES, THIENOPYRIDINES, AND PYRROLOPYRIMIDINES AS B-RAF INHIBITORS | WYETH (US) | 2009-05-07 | — | — | US | disclosed |
| WO-2009059272-A1 | THIENOPYRIMIDINES, THIENOPYRIDINES, AND PYRROLOPYRIMIDINES AS B-RAF INHIBITORS | WYETH (US) | 2009-05-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090118276-A1 | THIENOPYRIMIDINES, THIENOPYRIDINES, AND PYRROLOPYRIMIDINES AS B-RAF INHIBITORS | BRAF, ARAF, RAF1 | BRAF 1/4885KDR 616/4885PDGFRB 512/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.