Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 8/20 | 0.82 |
| ▸ | TEK | Q02763 | 5/20 | 0.53 |
| ▸ | KDR | P35968 | 5/20 | 0.50 |
| ▸ | KIT | P10721 | 2/20 | 0.50 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.50 |
| ▸ | TNNI3K | Q59H18 | 2/20 | 0.50 |
| ▸ | FLT1 | P17948 | 1/20 | 0.50 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.48 |
| ▸ | IDE | P14735 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3978525 | 0.90 | BRAF (1.00) | BRAFTEKKDRTRPV1IDE | |
| SCHEMBL3977510 | 0.87 | BRAF (0.66) | BRAFTEKKDRFLT1 | |
| SCHEMBL4196519 | 0.87 | BRAF (0.65) | BRAFKDRMAPK14MAPT | |
| SCHEMBL4188384 | 0.85 | BRAF (0.63) | BRAFTEKKDRKITMAPT | |
| SCHEMBL4198556 | 0.85 | CNR1 (0.62) | BRAFTEKMAPTHTTRAB9A | |
| SCHEMBL4188391 | 0.84 | BRAF (0.61) | BRAFTEKKDRKITFLT1 | |
| SCHEMBL4205684 | 0.83 | BRAF (0.88) | BRAFTEKKDRMAPK1MAPT | |
| SCHEMBL4200345 | 0.83 | BRAF (1.00) | BRAFTEKKDRMAPTMEN1 | |
| SCHEMBL4188378 | 0.82 | BRAF (0.57) | BRAFTEKKDRKITMAPK14 | |
| SCHEMBL3976206 | 0.82 | BRAF (0.84) | BRAFTEKKDRMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090118276-A1 | THIENOPYRIMIDINES, THIENOPYRIDINES, AND PYRROLOPYRIMIDINES AS B-RAF INHIBITORS | WYETH (US) | 2009-05-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090118276-A1 | THIENOPYRIMIDINES, THIENOPYRIDINES, AND PYRROLOPYRIMIDINES AS B-RAF INHIBITORS | BRAF, ARAF, RAF1 | BRAF 1/4885TEK 1005/4885KDR 616/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.