Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SSTR5 | P35346 | 14/20 | 0.44 |
| ▸ | HRH1 | P35367 | 4/20 | 0.44 |
| ▸ | SSTR1 | P30872 | 1/20 | 0.44 |
| ▸ | HTR2B | P41595 | 2/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3971377 | 0.86 | SSTR5 (0.41) | KDM4EALDH1A1NPSR1SSTR5HRH1 | |
| SCHEMBL3977762 | 0.81 | SSTR5 (0.52) | KDM4EALDH1A1SSTR5HRH1HTR2B | |
| SCHEMBL3977776 | 0.79 | SSTR5 (0.50) | KDM4EALDH1A1SSTR5HRH1HTR2B | |
| SCHEMBL3972896 | 0.79 | SSTR5 (0.43) | KDM4EALDH1A1NPSR1SSTR5 | |
| SCHEMBL4000512 | 0.78 | SSTR5 (0.46) | KDM4EALDH1A1NPSR1SSTR5HRH1 | |
| SCHEMBL2418270 | 0.78 | SSTR5 (0.56) | SSTR5HRH1SSTR1HTR2B | |
| SCHEMBL2415066 | 0.78 | SSTR5 (0.56) | KDM4EALDH1A1NPSR1RAB9ASSTR5 | |
| SCHEMBL3939333 | 0.78 | SSTR5 (0.47) | KDM4EALDH1A1NPSR1SSTR5HRH1 | |
| SCHEMBL3997966 | 0.76 | SSTR5 (0.44) | KDM4EALDH1A1NPSR1RAB9ASSTR5 | |
| SCHEMBL3971809 | 0.73 | SSTR5 (0.52) | SSTR5HRH1SSTR1HTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2054385-A2 | PHENYL, PYRIDINE AND QUINOLINE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2009-05-06 | — | — | EP | disclosed |
| WO-2008019967-A2 | PHENYL, PYRIDINE AND QUINOLINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-02-21 | — | — | WO | disclosed |