Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 12/20 | 0.42 |
| ▸ | NOS1 | P29475 | 11/20 | 0.42 |
| ▸ | NOS3 | P29474 | 8/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | IGF1R | P08069 | 3/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.40 |
| ▸ | KDR | P35968 | 2/20 | 0.40 |
| ▸ | PDE8A | O60658 | 1/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.39 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3928820 | 0.88 | CLK4 (0.42) | CYP2C9IGF1RFGFR1KDRROCK1 | |
| SCHEMBL3980913 | 0.88 | FGFR1 (0.50) | IGF1RFGFR1KDR | |
| SCHEMBL3934716 | 0.87 | NR3C2 (0.44) | CYP2C9IGF1RFGFR1KDRROCK1 | |
| SCHEMBL4089841 | 0.87 | FGFR1 (0.54) | NOS2NOS1NOS3CYP2C9IGF1R | |
| SCHEMBL3932128 | 0.85 | FGFR1 (0.46) | IGF1RFGFR1KDRDYRK1ACLK4 | |
| SCHEMBL3928183 | 0.79 | IGF1R (0.41) | CYP2C9IGF1RFGFR1KDRCLK4 | |
| SCHEMBL3942011 | 0.76 | IGF1R (0.40) | IGF1RFGFR1KDRROCK1 | |
| SCHEMBL24975420 | 0.75 | MAPT (0.48) | DYRK1ACLK4 | |
| SCHEMBL3928122 | 0.75 | KCNH2 (0.40) | NOS1ROCK1DYRK1A | |
| SCHEMBL3979717 | 0.75 | IGF1R (0.47) | NOS2NOS1CYP2C9IGF1RFGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009056886-A1 | PYRIMIDINE DERIVATIVES AND THEIR USE AS MODULATORS OF FGFR ACTIVITY | ASTRAZENECA AB (SE) | 2009-05-07 | — | — | WO | disclosed |