Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 5/20 | 0.50 |
| ▸ | KDR | P35968 | 4/20 | 0.50 |
| ▸ | IGF1R | P08069 | 4/20 | 0.50 |
| ▸ | INSR | P06213 | 1/20 | 0.46 |
| ▸ | FGFR2 | P21802 | 10/20 | 0.43 |
| ▸ | FGFR3 | P22607 | 7/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3932128 | 0.95 | FGFR1 (0.46) | FGFR1KDRIGF1RINSRFGFR2 | |
| SCHEMBL3928820 | 0.91 | CLK4 (0.42) | FGFR1KDRIGF1RINSR | |
| SCHEMBL3934716 | 0.90 | NR3C2 (0.44) | FGFR1KDRIGF1RFGFR2 | |
| SCHEMBL3976688 | 0.88 | NOS2 (0.42) | FGFR1KDRIGF1R | |
| SCHEMBL4086501 | 0.84 | FGFR1 (0.65) | FGFR1KDRIGF1RINSRFGFR2 | |
| SCHEMBL3928183 | 0.82 | IGF1R (0.41) | FGFR1KDRIGF1R | |
| SCHEMBL3982541 | 0.81 | IGF1R (0.77) | FGFR1KDRIGF1RINSRFGFR2 | |
| SCHEMBL5103566 | 0.80 | FGFR1 (0.59) | FGFR1KDRIGF1RINSRFGFR2 | |
| SCHEMBL4031157 | 0.79 | IGF1R (0.78) | FGFR1KDRIGF1RINSR | |
| SCHEMBL5096623 | 0.78 | IGF1R (0.77) | FGFR1KDRIGF1RINSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009056886-A1 | PYRIMIDINE DERIVATIVES AND THEIR USE AS MODULATORS OF FGFR ACTIVITY | ASTRAZENECA AB (SE) | 2009-05-07 | — | — | WO | disclosed |