Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPIN1 | Q9Y657 | 1/20 | 0.49 |
| ▸ | NSD2 | O96028 | 1/20 | 0.47 |
| ▸ | EHMT2 | Q96KQ7 | 3/20 | 0.46 |
| ▸ | EHMT1 | Q9H9B1 | 3/20 | 0.46 |
| ▸ | GBA1 | P04062 | 4/20 | 0.46 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.45 |
| ▸ | CCR4 | P51679 | 3/20 | 0.43 |
| ▸ | KMT5A | Q9NQR1 | 2/20 | 0.42 |
| ▸ | WHR1 | P49842 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | STAT6 | P42226 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3974312 | 0.82 | POLB (0.53) | GBA1POLBTSHRMAPK1SMN1; SMN2 | |
| SCHEMBL3977126 | 0.81 | GBA1 (0.49) | GBA1POLBTSHRMAPK1SMN1; SMN2 | |
| SCHEMBL3980771 | 0.76 | EHMT2 (0.51) | NSD2EHMT2EHMT1 | |
| SCHEMBL3980777 | 0.76 | WHR1 (0.40) | NSD2EHMT2EHMT1SLC2A1WHR1 | |
| SCHEMBL3976895 | 0.75 | NSD2 (0.49) | NSD2EHMT2EHMT1GBA1SLC2A1 | |
| SCHEMBL3976890 | 0.75 | SLC2A1 (0.46) | NSD2EHMT2EHMT1SLC2A1CCR4 | |
| SCHEMBL3975863 | 0.75 | KDM1A (0.49) | EHMT2GBA1SLC2A1KMT5AWHR1 | |
| SCHEMBL3972107 | 0.75 | LATS1 (0.50) | EHMT2EHMT1GBA1SLC2A1WHR1 | |
| SCHEMBL4238650 | 0.74 | PDE5A (0.58) | EHMT2EHMT1GBA1SLC2A1WHR1 | |
| SCHEMBL3976324 | 0.72 | SLC2A1 (0.56) | SLC2A1WHR1SMN1; SMN2KDM4ESTAT6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7547702-B2 | 4-amino-quinazolines | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2009-06-16 | — | — | US | disclosed |
| US-20060019974-A1 | Glycoprotein antagonist; anticholesterol agents; cardiovascular disorders; strokes; antiischemic agents | ORTHO-MCNEIL PHARMACEUTICALS, INC. | 2006-01-26 | — | — | US | disclosed |
| WO-2004030672-A1 | USE OF 4 AMINO-QUINAZOLINES AS ANTI CANCER AGENTS | MERCK PATENT GMBH (DE) | 2004-04-15 | — | — | WO | disclosed |
| CN-1474815-A | 4-amino-quinazolines | Ĭ��ר���ɷ�����˾ | 2004-02-11 | — | — | CN | disclosed |
| EP-1318984-A1 | 4-AMINO-QUINAZOLINES | MERCK PATENT GmbH (DE) | 2003-06-18 | — | — | EP | disclosed |
| WO-2002024667-A1 | 4-AMINO-QUINAZOLINES | MERCK PATENT GMBH (DE) | 2002-03-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060019974-A1 | Glycoprotein antagonist; anticholesterol agents; cardiovascular disorders; strokes; antiischemic agents | SERPINA3, APOL1, MGAT3 | SPIN1 3461/4885NSD2 4824/4885EHMT2 4873/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.