Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS5 | Q9UNA0 | 12/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | CCR6 | P51684 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3980733 | 0.91 | ADAMTS5 (0.38) | ADAMTS5HIF1AKDM4EALOX12ALDH1A1 | |
| SCHEMBL3976222 | 0.86 | ADAMTS5 (0.41) | ADAMTS5HIF1AKDM4EALOX12ALDH1A1 | |
| SCHEMBL3978316 | 0.84 | ADAMTS5 (0.46) | ADAMTS5 | |
| SCHEMBL1817671 | 0.83 | HIF1A (0.39) | ADAMTS5HIF1AKDM4EALOX12ALDH1A1 | |
| SCHEMBL1812223 | 0.81 | HIF1A (0.35) | ADAMTS5HIF1AKDM4EALOX12ALDH1A1 | |
| SCHEMBL3982622 | 0.81 | HIF1A (0.39) | ADAMTS5HIF1AKDM4EALOX12ALDH1A1 | |
| SCHEMBL1815431 | 0.78 | ADAMTS5 (0.39) | ADAMTS5HIF1AKDM4EALOX12ALDH1A1 | |
| SCHEMBL14033046 | 0.77 | KDM4E (0.36) | ADAMTS5HIF1AKDM4EALOX12ALDH1A1 | |
| SCHEMBL1812739 | 0.76 | ADAMTS5 (0.45) | ADAMTS5 | |
| SCHEMBL4037188 | 0.74 | HIF1A (0.45) | ADAMTS5HIF1AKDM4EALOX12ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2056823-A2 | 8-HYDROXYQUINOLINE COMPOUNDS AND METHODS THEREOF | Wyeth (US) | 2009-05-13 | — | — | EP | disclosed |
| WO-2008024922-A2 | 8-HYDROXYQUINOLINE COMPOUNDS AND METHODS THEREOF | WYETH (US) | 2008-02-28 | — | — | WO | disclosed |