Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 17/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.35 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.34 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL349113 | 0.94 | HSD11B1 (0.61) | HSD11B1CYP2D6NPY5R | |
| SCHEMBL347595 | 0.94 | HSD11B1 (0.61) | HSD11B1CYP2D6NPY5R | |
| SCHEMBL348959 | 0.92 | HSD11B1 (0.66) | HSD11B1CYP2D6NPY5RAKR1C3AKR1C2 | |
| SCHEMBL350306 | 0.92 | HSD11B1 (0.66) | HSD11B1CYP2D6NPY5RAKR1C3AKR1C2 | |
| SCHEMBL349487 | 0.81 | HSD11B1 (0.83) | HSD11B1CYP2D6NPY5R | |
| SCHEMBL350246 | 0.79 | HSD11B1 (0.66) | HSD11B1CYP2D6NPY5R | |
| SCHEMBL350378 | 0.79 | HSD11B1 (0.66) | HSD11B1CYP2D6NPY5R | |
| SCHEMBL351411 | 0.79 | HSD11B1 (0.60) | HSD11B1CYP2D6 | |
| SCHEMBL349038 | 0.79 | HSD11B1 (0.60) | HSD11B1CYP2D6 | |
| SCHEMBL351109 | 0.79 | HSD11B1 (0.82) | HSD11B1CYP2D6NPY5R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756063-A4 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORP (US) | 2009-03-25 | — | — | EP | claimed |
| EP-1756063-A1 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | Incyte Corporation (US) | 2007-02-28 | — | — | EP | claimed |
| WO-2005110992-A1 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORPORATION (US) | 2005-11-24 | — | — | WO | claimed |