Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 3/20 | 0.60 |
| ▸ | KCNQ2 | O43526 | 2/20 | 0.60 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.60 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.60 |
| ▸ | KMO | O15229 | 1/20 | 0.45 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.45 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.44 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.44 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.44 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.44 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.44 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6645521 | 1.00 | CYP3A4 (0.60) | CYP3A4KCNQ2KCNQ3CYP1A2CYP19A1 | |
| SCHEMBL6858656 | 0.87 | MEN1 (0.47) | CYP3A4KCNQ2KCNQ3CYP1A2CYP19A1 | |
| SCHEMBL782021 | 0.87 | MEN1 (0.47) | CYP3A4KCNQ2KCNQ3CYP1A2CYP19A1 | |
| SCHEMBL6626168 | 0.87 | MEN1 (0.47) | CYP3A4KCNQ2KCNQ3CYP1A2CYP19A1 | |
| SCHEMBL17966968 | 0.87 | LMNA (0.48) | CYP3A4KCNQ2KCNQ3CYP1A2CYP19A1 | |
| SCHEMBL21378587 | 0.87 | LMNA (0.48) | CYP3A4KCNQ2KCNQ3CYP1A2CYP19A1 | |
| SCHEMBL21378590 | 0.87 | LMNA (0.48) | CYP3A4KCNQ2KCNQ3CYP1A2CYP19A1 | |
| SCHEMBL5674426 | 0.86 | CYP3A4 (0.47) | CYP3A4KCNQ2KCNQ3CYP1A2CYP19A1 | |
| SCHEMBL14830816 | 0.85 | MEN1 (0.47) | CYP3A4KCNQ2KCNQ3CYP1A2CYP19A1 | |
| SCHEMBL6684783 | 0.85 | KCNQ3 (0.45) | CYP3A4KCNQ2KCNQ3CYP1A2CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009050227-A1 | PYRIDAZINE DERIVATIVES FOR INHIBITING BETA AMYLOID PEPTIDE PRODUCTION | GLAXO GROUP LIMITED (GB) | 2009-04-23 | — | — | WO | disclosed |
| WO-2009050227-A1 | PYRIDAZINE DERIVATIVES FOR INHIBITING BETA AMYLOID PEPTIDE PRODUCTION | GLAXO GROUP LIMITED (GB) | 2009-04-23 | — | — | WO | disclosed |