Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H3 | Q13133 | 6/20 | 0.52 |
| ▸ | NR1H2 | P55055 | 5/20 | 0.52 |
| ▸ | BCHE | P06276 | 2/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.44 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.43 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HTR1D | P28221 | 1/20 | 0.41 |
| ▸ | HTR1B | P28222 | 1/20 | 0.41 |
| ▸ | GPR88 | Q9GZN0 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3979283 | 1.00 | NR1H3 (0.52) | NR1H3NR1H2BCHEFFAR1ABCB1 | |
| SCHEMBL3978325 | 0.91 | BCHE (0.44) | NR1H3NR1H2BCHEFFAR1ABCB1 | |
| SCHEMBL3978329 | 0.91 | BCHE (0.44) | NR1H3NR1H2BCHEFFAR1ABCB1 | |
| SCHEMBL4950334 | 0.83 | BCHE (0.54) | NR1H3NR1H2BCHEABCB1KDM4E | |
| SCHEMBL4950338 | 0.83 | BCHE (0.54) | NR1H3NR1H2BCHEABCB1KDM4E | |
| SCHEMBL4947620 | 0.83 | BCHE (0.54) | NR1H3NR1H2BCHEABCB1KDM4E | |
| SCHEMBL4086901 | 0.81 | ALOX15 (0.56) | NR1H3NR1H2PLA2G4BKDM4ETDP1 | |
| SCHEMBL3984308 | 0.79 | NR1H3 (0.49) | NR1H3NR1H2BCHEFFAR1ABCB1 | |
| SCHEMBL3984311 | 0.79 | NR1H3 (0.49) | NR1H3NR1H2BCHEFFAR1ABCB1 | |
| SCHEMBL11805244 | 0.78 | PLA2G4B (0.52) | NR1H3NR1H2PLA2G4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7560586-B2 | Acid and ester compounds and methods of using the same | SMITHKLINE BEECHAM CORPORATION (US) | 2009-07-14 | — | — | US | disclosed |
| US-20060041164-A1 | Acid and ester compounds and methods of using the same | GLAXOSMITHKLINE LLC | 2006-02-23 | — | — | US | disclosed |
| EP-1487776-A4 | ACID AND ESTER COMPOUNDS AND METHODS OF USING THE SAME | SMITHKLINE BEECHAM CORP (US) | 2005-05-25 | — | — | EP | disclosed |
| EP-1487776-A1 | ACID AND ESTER COMPOUNDS AND METHODS OF USING THE SAME | SMITHKLINE BEECHAM CORPORATION (US) | 2004-12-22 | — | — | EP | disclosed |
| WO-2003082802-A1 | ACID AND ESTER COMPOUNDS AND METHODS OF USING THE SAME | SMITHKLINE BEECHAM CORPORATION (US) | 2003-10-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060041164-A1 | Acid and ester compounds and methods of using the same | NR1H3, NR1H2, PPARA | NR1H3 1/4885NR1H2 2/4885BCHE 1547/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.